Protein Alignment Cyp4ac3 and cyp-25A1

DIOPT Version :10

• Sequence 1: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_497775.3
• Gene: cyp-25A1 / 183247
• WormBaseID: WBGene00007963
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 545
• Identity: 124/545 - (22%)
• Similarity: 227/545 - (41%)
• Gaps: 89/545 - (16%)

  Fly     5 LLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNL-------DL 62
            |:.|||:|......:      |.||:..:|.:..:...|..     |....|..||       :.
 Worm     4 LILSSLVISIFTFFI------YIILARRERFKLREKIGLSG-----PEPHWFLGNLKQTAERKEK 57

  Fly    63 LNLTPAN-IFSYIRESTAKANGQNYIWNFLFAPEYNIV--RAEDAEEIFQSTKITTKNMS----- 119
            |....|| .|:.:.|...:..|      ..:..:.|||  ..:|.:|:|      .||.|
 Worm    58 LGYDDANRWFNELHEQYGETFG------IYYGSQMNIVISNEKDIKEVF------IKNFSNFSDR 110

  Fly   120 -----YELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNV-- 177
                 || ........|:.|....|...|..:.|.|....:::.......:...|:.||.:..
 Worm   111 SVPSIYE-ANQLTASLLMNSYSSGWKHTRSAIAPIFSTGKMKAMQETINSKVDLFLDILREKASS 174

  Fly   178 GFELELNQIIPQFTLNNICETALGVKLDDMSEGNEY-----RKAIHDFEIVFNQRMCNPLMFFNW 237
            |.:.::.......||:.|.:.|..:..:...:.|:.     :|.|.:.:|..::.:...::....
 Worm   175 GQKWDIYDDFQGLTLDVIGKCAFAIDSNCQRDRNDVFYVNAKKYISNIDIRHSKIIAASVLLPEL 239

  Fly   238 YFFLFGDYKKYSRI----LRTIHGFSSGIIQRKRQQFKQKQLGQ----VDEFGKKQRYAMLDTLL 294
            ..|....| ||:.:    :..:.|.|: :.:|:|.       |:    ||         :|..||
 Worm   240 STFWKALY-KYTPLADAEIPLVEGLSN-VYERRRG-------GEGSDSVD---------LLKLLL 286

  Fly   295 AAEAEGK--IDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEV 357
            ..|.:..  :..|.:.:....|:..||:||||::.:...||:.:.:||::.|||:.:..|: ..:
 Worm   287 NREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEAKEN-GGL 350

  Fly   358 SMFQFNELIHLECVIKESLRLFPSAPI---IGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARH 419
            :....:.:.:|:||.||:||.:|  |:   |.|.|.|:..:.|...||.|.:....:.:.|:..:
 Worm   351 TYDSIHNMKYLDCVYKETLRFYP--PVIHFIRRLCREDITIRGQFYPKGAIVVCLPHTVHRNPEN 413

  Fly   420 FPKPNQFLPERFLPEN-SVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQL 483
            :..|.:|.||||  || ........::||..|||.|:|.:|..:|.|..:..::..|:|......
 Worm   414 WDSPEEFHPERF--ENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIVKLLDTFELKQFEGE 476

  Fly   484 EDLTFE-NGIVLRTQQNIKVKFEAR 507
            .||..: ||:::|....:::..:.|
 Worm   477 ADLIPDCNGVIMRPNDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	CYP4	87..502	CDD:410721	103/448 (23%)
cyp-25A1	NP_497775.3	CYP3A-like	73..495	CDD:410678	104/457 (23%)