DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	527	Identity:	162/527 - (30%)
Similarity:	253/527 - (48%)	Gaps:	72/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLIGALWLLLRQLNKTYFILSLCKRVRTADGSPL---------------ESKVFVVPGKTRFGNN 59
            ||.||.|:|.|.|...|.....|.|:|.....|.               ||..|:    |..|::
Mouse    23 LLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWFWGHLALMKNNEESMQFI----THLGHD 83

  Fly    60 LDLLNLTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAED----AEEIFQSTKITTKNMS- 119
            ...::|:                     |   ..|.|.|:|...    |..:..|..:..|.|:
Mouse    84 FHDVHLS---------------------W---VGPVYPILRLVHPNFIAPLLQASAAVAPKEMTL 124

  Fly   120 YELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE----SKKFIKILDKNVGFE 180
            |..::|:||||||:|...||...|:.|||||||:||:|::.||.:.    ..|:..:..|... .
Mouse   125 YGFLKPWLGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTS-R 188

  Fly   181 LELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDY 245
            |::.:.|...||:::.:....|..:.....::|..||.:...:..:|...|.::.:..::|..|.
Mouse   189 LDMFEHISLMTLDSLQKCIFSVDSNCQESDSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADG 253

  Fly   246 KKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAE-GK-IDHQGIC 308
            :::.:....:|.|:..:|:.:|.....:.:..:....|.:....:|.||.||.| || :.::.|.
Mouse   254 RRFRKACDLVHNFTDAVIKERRSTLNTQGVEFLKAKAKTKTLDFIDVLLMAEDEHGKGLSNEDIR 318

  Fly   309 DEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIHLECV 371
            .|.:||||||:|||:::|.:.|..||.|.:.||||.:|:|:|..|.|  |:......:|..|...
Mouse   319 AEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFLTMC 383

  Fly   372 IKESLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPEN 435
            |||||||.|...:|.|.|.::.:: :|..:||.....|.|:.:..:...:|.|..:.|.||.|||
Mouse   384 IKESLRLHPPVLLISRCCTQDVLLPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPEN 448

  Fly   436 SVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLED----------LTFEN 490
            ...|.|.||:|||||.||||||.|.:.||||.||..:..|::||    :|          |..|.
Mouse   449 PQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRILP----DDKEPRRKPELILRAEG 509

  Fly   491 GIVLRTQ 497
            |:.||.:
Mouse   510 GLWLRVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	146/471 (31%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	148/493 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850