DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and CYP19A1

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens

Alignment Length:	523	Identity:	119/523 - (22%)
Similarity:	210/523 - (40%)	Gaps:	105/523 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLRQLNKTYF-ILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLTPANIFSYIRESTAK 80
            ::|..||..:: |.|:......|...|    |.::.|       |.||      :::|  |.|:.
Human     1 MVLEMLNPIHYNITSIVPEAMPAATMP----VLLLTG-------LFLL------VWNY--EGTSS 46

  Fly    81 ANGQNY-------------IW-------NFLFAPEYNIVRAE------DAEEIFQSTKITTKN-- 117
            ..|..|             :|       |:     ||.|..|      ..||    |.|.:|:
Human    47 IPGPGYCMGIGPLISHGRFLWMGIGSACNY-----YNRVYGEFMRVWISGEE----TLIISKSSS 102

  Fly   118 ----MSYELIRPFLGDGL---LISIDQK----------WHTRRKTLTPAFHFNILQSFLSIFKEE 165
                |.:.......|..|   .|.:.:|          |.|.|.....|.....|...:::..|.
Human   103 MFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAES 167

  Fly   166 SKKFIKILDK--NVGFELELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRM 228
            .|..:..|::  |....:::..::.:..|:......|.:.||:    :.....|..:...:...:
Human   168 LKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL 228

  Fly   229 CNPLMFF--NWYFFLFGDYKKYSRILRTIHGFSSGIIQRKRQQFK-QKQLGQVDEFGKKQRYAML 290
            ..|.:||  :|.      ||||.:.::.:......:|..||::.. :::|.:..:|..:
Human   229 IKPDIFFKISWL------YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATE------ 281

  Fly   291 DTLLAAEAEGKIDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID 355
              |:.||..|.:..:.:...:...:....||.|.||.|.|.|:|.|.:|:|...:|:|.:..:.|
Human   282 --LILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD 344

  Fly   356 EVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHF 420
             :.:....:|..:|..|.||:|..|...::.|..:|:.|::|..:.|...|.::| ..|.....|
Human   345 -IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNI-GRMHRLEFF 407

  Fly   421 PKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNF--KLLPATQL 483
            ||||:|..|.| .:|...|:   |.||..|||.|.|:...::.:|.:|..::|.|  |.|....:
Human   408 PKPNEFTLENF-AKNVPYRY---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468

  Fly   484 EDL 486
            |.:
Human   469 ESI 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	111/488 (23%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	101/433 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950