Protein Alignment Cyp4ac3 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 146/536 - (27%)
• Similarity: 262/536 - (48%)
• Gaps: 66/536 - (12%)

  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNL 65
            |.:::|..|.|:|.:..:|:..:....:|.|.|.|:.     ...:.:::....:|       ..
Human     1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQL-----YLHRQWLLKALQQF-------PC 53

  Fly    66 TPAN-IFSYIRE--------------STAKANGQNYIWN-----FLFAPEYN--IVRAEDAEEIF 108
            .|:: :|.:|:|              .|..:...:::|.     .|:.|:|.  |:...|.:
Human    54 PPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPK--- 115

  Fly   109 QSTKITTKNMSYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKIL 173
                   .:.||..:.|::|.|||:...|.|...|:.||||||::||:.::.:..:..:..:...
Human   116 -------SHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKW 173

  Fly   174 DKNVGFE--LELNQIIPQFTLNNICETAL----GVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPL 232
            ::.:|.:  ||:.|.:...||:.|.:.|.    .:::|..|:  .|.:||.|...:...|:.|..
Human   174 EELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQ--SYIQAISDLNNLVFSRVRNAF 236

  Fly   233 MFFNWYFFLFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAE 297
            ...:..:.|....:...|..:..|..:..:||.::.|.:::  |::::..:|:....||.||.|:
Human   237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKE--GELEKIKRKRHLDFLDILLLAK 299

  Fly   298 AE-GKI-DHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMF 360
            .| |.| ..:.:..||:||||.|:|||::.:.:.|..||.|...||||.||:..|..|...::..
Human   300 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWN 364

  Fly   361 QFNELIHLECVIKESLRLFPSAPIIGR-TCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPN 424
            ..:::.:....|||:|||:|..|.||| .....:..:|..|||...:.:.||.:..:.:.:|.|.
Human   365 HLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPE 429

  Fly   425 QFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP-ATQLE---- 484
            .|.|.||.|.::  :|..||:|||.|.|||||::|.:.|:||..|..:..|:||| .|::.
Human   430 VFDPFRFAPGSA--QHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIA 492

  Fly   485 --DLTFENGIVLRTQQ 498
              .|..:|||.||.::
Human   493 RLVLKSKNGIHLRLRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	CYP4	87..502	CDD:410721	130/435 (30%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	129/446 (29%)