DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	494	Identity:	128/494 - (25%)
Similarity:	231/494 - (46%)	Gaps:	72/494 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VPGKTRFGNNLDLLNLTPANIFSYIRESTAKANGQNY-----IWN-------FLFAPEYNIVRAE 102
            :||.|    .|.||    .|:.|| |:...|.:.:.|     :|.       .|...:.:::|..
Human    38 IPGPT----PLPLL----GNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTV 93

  Fly   103 DAEEIFQSTKITTKNMSYELIRP--FLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE 165
            ..:|.:   .:.|...|   :.|  |:...:.::.|::|...|..|:|.|....|:....|..:.
Human    94 LVKECY---SVFTNRRS---LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152

  Fly   166 SKKFIKILDKNV--GFELELNQIIPQFTLNNICETALGVKLDDMSEGN----EYRKAIHDFEIVF 224
            ....::.|.:..  |..:.|..|...::::.|..|:.||.:|.::...    |..|....|..:
Human   153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFL- 216

  Fly   225 NQRMCNPLMFFNWYF-FLFGDYKKYSRIL---RTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQ 285
                 :||......| ||...::..:..|   .||:..|..:.:.|:.:...||..::|..
Human   217 -----DPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL---- 272

  Fly   286 RYAMLDTLLAAEAEGKIDHQGICD-----EVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYE 345
             ..|:|:..:.|.|   .|:.:.|     :...|:|.||:|||:.|.|||..||.|.|||::..:
Human   273 -QLMIDSQNSKETE---SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333

  Fly   346 ELQDL-----PEDIDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQ 405
            |:..:     |...|.|...::     |:.|:.|:|||||.|..:.|||.::..:||:.:||.:.
Human   334 EIDAVLPNKAPPTYDAVVQMEY-----LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSM 393

  Fly   406 ISIHIYDIMRDARHFPKPNQFLPERF-LPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLA 469
            :.|..|.:..|.:::.:|.:|.|||| ..::|::  |:.:.||..|||||||.:|.::.:|:.|.
Human   394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID--PYIYTPFGTGPRNCIGMRFALMNMKLALI 456

  Fly   470 AVIRNFKLLPATQLE-DLTFENGIVLRTQQNIKVKFEAR 507
            .|::||...|..:.: .|..:...:|:.::.|.:|.::|
Human   457 RVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	126/488 (26%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	126/488 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910