Protein Alignment Cyp4ac3 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 128/494 - (25%)
• Similarity: 231/494 - (46%)
• Gaps: 72/494 - (14%)

  Fly    50 VPGKTRFGNNLDLLNLTPANIFSYIRESTAKANGQNY-----IWN-------FLFAPEYNIVRAE 102
            :||.|    .|.||    .|:.|| |:...|.:.:.|     :|.       .|...:.:::|..
Human    38 IPGPT----PLPLL----GNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTV 93

  Fly   103 DAEEIFQSTKITTKNMSYELIRP--FLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE 165
            ..:|.:   .:.|...|   :.|  |:...:.::.|::|...|..|:|.|....|:....|..:.
Human    94 LVKECY---SVFTNRRS---LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152

  Fly   166 SKKFIKILDKNV--GFELELNQIIPQFTLNNICETALGVKLDDMSEGN----EYRKAIHDFEIVF 224
            ....::.|.:..  |..:.|..|...::::.|..|:.||.:|.::...    |..|....|..:
Human   153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFL- 216

  Fly   225 NQRMCNPLMFFNWYF-FLFGDYKKYSRIL---RTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQ 285
                 :||......| ||...::..:..|   .||:..|..:.:.|:.:...||..::|..
Human   217 -----DPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL---- 272

  Fly   286 RYAMLDTLLAAEAEGKIDHQGICD-----EVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYE 345
             ..|:|:..:.|.|   .|:.:.|     :...|:|.||:|||:.|.|||..||.|.|||::..:
Human   273 -QLMIDSQNSKETE---SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333

  Fly   346 ELQDL-----PEDIDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQ 405
            |:..:     |...|.|...::     |:.|:.|:|||||.|..:.|||.::..:||:.:||.:.
Human   334 EIDAVLPNKAPPTYDAVVQMEY-----LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSM 393

  Fly   406 ISIHIYDIMRDARHFPKPNQFLPERF-LPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLA 469
            :.|..|.:..|.:::.:|.:|.|||| ..::|::  |:.:.||..|||||||.:|.::.:|:.|.
Human   394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID--PYIYTPFGTGPRNCIGMRFALMNMKLALI 456

  Fly   470 AVIRNFKLLPATQLE-DLTFENGIVLRTQQNIKVKFEAR 507
            .|::||...|..:.: .|..:...:|:.::.|.:|.::|
Human   457 RVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	CYP4	87..502	CDD:410721	114/445 (26%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	114/450 (25%)