DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	523	Identity:	153/523 - (29%)
Similarity:	251/523 - (47%)	Gaps:	52/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIALLGSSLLIGALWLLLRQLNKTYF-ILSLC----KRVRTADGSPLESKVFVVPGKTRFGNNL 60
            |.::.|..||....||..:..|..|.. :|||.    |..|..|..|...|.::      ||:.|
Mouse     1 MALSFLSPSLSRLGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWL------FGHAL 59

  Fly    61 DLLN-------LTPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNM 118
            ::..       :|....|.|...          :|...|....||...:.|:.:: |........
Mouse    60 EIQKTGGLDKVVTWTEQFPYAHP----------LWLGQFIVFLNIYEPDYAKAVY-SRGDPKAAY 113

  Fly   119 SYELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESK----KFIKILDKNVGF 179
            .|:....::|.|||:....||...||.|||.||:::|:.:::||.|.::    |:.|...:|..|
Mouse   114 VYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSF 178

  Fly   180 ELELNQIIPQFTLNNICETALGVKLDDMSEG-NEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFG 243
            ::..:  :....|:.:.:...|.....:|.. |.|..|:.|..::..||:.:.....::.::|..
Mouse   179 DIFCD--VGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTP 241

  Fly   244 DYKKYSRILRTIHGFSSGII-QRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEG--KIDHQ 305
            ..:::.|..:..|..:..:| |||.....:|:..::.|   ::....||.||.|..|.  |:...
Mouse   242 HGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQE---RRHLDFLDILLGARDESGIKLSDA 303

  Fly   306 GICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHLEC 370
            .:..||:||||.|:|||::.:.:.|..:||:...|:||.||::::..|.|........::.:|..
Mouse   304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQWDDLAQMTYLTM 368

  Fly   371 VIKESLRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPE 434
            .:||..||:|..|.:.|...:. :.::|..||..:.||:|||.:.|::..:|.|..|.|.||.||
Mouse   369 CMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPE 433

  Fly   435 NSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP--------ATQLEDLTFENG 491
            |...||||||:||||||||||||:|.:.|:||:.|..:..|:..|        ..|| .|..:||
Mouse   434 NMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQL-ILRSKNG 497

  Fly   492 IVL 494
            |.|
Mouse   498 IHL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	137/468 (29%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	138/475 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850