DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac3 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	521	Identity:	169/521 - (32%)
Similarity:	268/521 - (51%)	Gaps:	39/521 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTR-FGNNLDLLNL 65
            |:.|    |::||.|||.|.|..||......:|:|          .|..|.|.. |..:|.|  :
Human    19 WLLL----LVVGASWLLARILAWTYAFYHNGRRLR----------CFPQPRKQNWFLGHLGL--V 67

  Fly    66 TPANIFSYIRESTAKANGQNYI-WNFLFAPEYNIVRAEDAEEIFQ-STKITTKN-MSYELIRPFL 127
            ||......:.........|.:: |.....|..|:...:....:.. |..||.|: :.|:.::|:|
Human    68 TPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWL 132

  Fly   128 GDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKILDKNVGFE----LELNQIIP 188
            |||||:|:..||...|:.||||||||||:.::.|| .:|...:....:.:..|    |::.:.|.
Human   133 GDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIF-SKSANIMHAKWQRLAMEGSTCLDVFEHIS 196

  Fly   189 QFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILR 253
            ..||:::.:.......:...:.:||..||.:...:..:|......:.::.:||....:::.|..|
Human   197 LMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACR 261

  Fly   254 TIHGFSSGIIQRKRQQFKQKQLGQVDEF----GKKQRYAMLDTLLAAE-AEGK-IDHQGICDEVN 312
            .:|.|:..:||.:|:....:   .||:|    .|.:....:|.||.:| ..|| :..:.|..|.:
Human   262 LVHDFTDAVIQERRRTLTSQ---GVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEAD 323

  Fly   313 TFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIHLECVIKES 375
            ||||||:|||::.|.:.|..||.|.:.||||.:|:|:|.:|.:  |:......:|..|...:|||
Human   324 TFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKES 388

  Fly   376 LRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNR 439
            |||.|..|...|.|.::.|: :..|:||....:|:|:.|..:...:|.|..:.|.||.|||:..|
Human   389 LRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKR 453

  Fly   440 HPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQQNIKVKF 504
            .|.||:||||||||||||||.:.|:||:||..:..|::||..:....|.|  ||||.:..:.::.
Human   454 SPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPE--IVLRAEDGLWLRV 516

  Fly   505 E 505
            |
Human   517 E 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	153/469 (33%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	149/459 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850