DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	499	Identity:	146/499 - (29%)
Similarity:	249/499 - (49%)	Gaps:	47/499 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AAP-LVIFIFRKLW--AH-LNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTS 68
            |:| |::.:....|  || |..||.....|:|:|.         ....|.:..|..:..:||.|.
Human    16 ASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRC---------FPQPPRRNWFWGHQGMVNPTE 71

  Fly    69 ESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLIT--KNMIYELLKPFLGEG 131
            |.:....:..:...:|.. :|....:|:.::...:....::.:|..|.  ....|..|:|:||:|
Human    72 EGMRVLTQLVATYPQGFK-VWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDG 135

  Fly   132 LLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLH---QSVNME----LELNQVIP 189
            ||:|...||...|:.|||||||.:|:.::.||.|..|    ::|   |.:..|    |::.:.|.
Human   136 LLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVN----IMHAKWQLLASEGSACLDMFEHIS 196

  Fly   190 QFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLK 254
            ..||:::.:...........:...|..:|..:..::.:|......:....::|..|.::.....:
Human   197 LMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACR 261

  Fly   255 IAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLD----TLLAAEADG-QIDHQGICDEVNT 314
            :.|:|:..:|::||....|.  |.:|....|.:...||    .||:.:.|| ::..:.|..|.:|
Human   262 LVHDFTDAVIQERRRTLPSQ--GVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADT 324

  Fly   315 FMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDS-------DDISVFQFNELVYMECV 372
            |||||:|||::.|.:.|..||.|.:.|::|.:|::.|..|.       ||::     .|.::...
Human   325 FMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA-----HLPFLTMC 384

  Fly   373 IKESLRLFPSVPFIGRRCVEEGVV-NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPEN 436
            :||||||.|.||.|.|...::.|: :|.::||.....|.::....:...:.:|:::.|.||.|||
Human   385 MKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPEN 449

  Fly   437 TVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILP 480
            ...|.|.||:|||||.||||||.||:.|:||:||..:..|::||
Human   450 IKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	133/446 (30%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	13/49 (27%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	134/454 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850