DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and cyp4v2.2

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001072667.1	Gene:	cyp4v2.2 / 780124	XenbaseID:	XB-GENE-977085	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	427	Identity:	157/427 - (36%)
Similarity:	252/427 - (59%)	Gaps:	12/427 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSF 159
            |...:..|:..|.:|.|||.:.|..:|:.|.|:||:|||.||.:||.||||.:||.|||.:|..|
Frog    92 PFIVVYHADTVEPVLSSSKHMDKAFLYKFLHPWLGKGLLTSTGEKWRSRRKMITPTFHFAILSEF 156

  Fly   160 LIIFKEECNKLVKVLHQSVNME-LELNQVIPQFTLNNVCETALGVKLDDLS-EGIRYRQSIHAIE 222
            |.:..|:...||:.|...|:.| .:....:....|:.:.|||:|.|:...| ....|.|:|:.:.
Frog   157 LEVMNEQSKILVEKLQTHVDGESFDCFMDVTLCALDIISETAMGRKIQAQSNRDSEYVQAIYKMS 221

  Fly   223 EVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSN-IIEKRRSLFKSNQLGQE-----DE 281
            :::|:|...|:.:....:....|.::...||||.|.|:.. |:|:...|.|..:..:|     .|
Frog   222 DIIQRRQKMPWLWLDFLYAHLRDGKEHDKNLKILHSFTDKAILERAEELKKMGEQKKEHCDSDPE 286

  Fly   282 FGK-KQRYAMLDTLLAA--EADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKK 343
            ..| |:|.|.||.||.|  :|..::.:..|.:||:||||||:|||:..|.::|.:|..|.:.|::
Frog   287 SDKPKKRSAFLDMLLMATDDAGNKMSYMDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQ 351

  Fly   344 CYEEIKYLPDDSD-DISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQI 407
            .::|:..:...|| .:::....:|.|:|.|||||||::||||..||...|:..:.|..:||...:
Frog   352 VHKELDEVFGKSDRPVTMDDLKKLRYLEAVIKESLRIYPSVPLFGRTVTEDCSIRGFHVPKGVNV 416

  Fly   408 NIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAV 472
            .|..|.:.||..:|..|:.|:|:||||||...|:|:|::|||||.||||||:||::|.||:|:::
Frog   417 VIIPYALHRDPEYFPEPEEFRPERFFPENASGRNPYAYIPFSAGLRNCIGQRFALMEEKVVLSSI 481

  Fly   473 IRNFKILPVTLLDDLTFENGIVLRTKQNIKVKLVHRE 509
            :||:.:......::|.....::||.:..:.:||.:||
Frog   482 LRNYWVEASQKREELCLLGELILRPQDGMWIKLKNRE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	153/421 (36%)
cyp4v2.2	NP_001072667.1	p450	45..509	CDD:365848	153/416 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010