DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	466	Identity:	135/466 - (28%)
Similarity:	232/466 - (49%)	Gaps:	62/466 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 ESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVR----AEEAEEILQSSKLITKNMI-YELLKPFL 128
            :|:....|||..        |:.  .|::.::|    |.....:|..:.:..|:.: |..|||:|
Mouse    78 QSLVRTFRDACC--------WWV--GPLHPVIRIFHPAFIKPVVLAPALVAPKDTVFYRFLKPWL 132

  Fly   129 GEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLH-------QSVNMELELNQ 186
            |:|||:||..||...|:.|||||||.:|:.::.:|.:..|    ::|       ...:..|.:.:
Mouse   133 GDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTN----IMHAKWQRLASKGSAYLNMFE 193

  Fly   187 VIPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVN 251
            .|...||:::.:.......:...:...|..:|..:..::.:|......:..::::|..|..:...
Mouse   194 HISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRK 258

  Fly   252 NLKIAHEFSSNII-EKRRSLFKSNQLGQEDEFGKKQRYAMLD----TLLAAEADGQ-IDHQGICD 310
            ..::.|:|:..:| |:||:|...   |..|....|.:...||    .||:.:..|: :..:.|..
Mouse   259 ACRLVHDFTDAVIRERRRTLLDQ---GGVDVLKAKAKAKTLDFIDVLLLSKDEHGKALSDEDIRA 320

  Fly   311 EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDS-------DDISVFQFNELVY 368
            |.:||||.|:|||::.|.:.|..||.|.:.|::|.:|::.|..|.       ||::     :|.:
Mouse   321 EADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLA-----QLPF 380

  Fly   369 MECVIKESLRLFPSVPFIGRRCVEEGVV-NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRF 432
            :...|||||||.|.|..|.|.|.::.|: :|.::||.....|.::....:...:.:|:::.|.||
Mouse   381 LTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEVYDPFRF 445

  Fly   433 FPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDD----------L 487
            ..:|...|.|.||:|||||.||||||.||:.|:||.||..:..|::||    ||          |
Mouse   446 DADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLP----DDKEPRRKPELIL 506

  Fly   488 TFENGIVLRTK 498
            ..|.|:.|:.:
Mouse   507 RAEGGLWLKVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	135/466 (29%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	135/463 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850