DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	506	Identity:	151/506 - (29%)
Similarity:	241/506 - (47%)	Gaps:	59/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESIFNFMRDASAKAKGRNYLWY 90
            ||.....|.|:         |.....|.|..|..:..::....|.: ..:.:.....:..:..|.
Mouse    38 TYSFYENCSRL---------SCFPQPPKKNWFSGHLGMIQSNEEGM-QLVTEMGQTFQDVHLFWL 92

  Fly    91 FFHAPMYNIVRAEEAEEILQSSKLIT-KNMIY-ELLKPFLGEGLLISTDQKWHSRRKALTPAFHF 153
            ....|:..||.......:||:..|:. |:|.: ..|||:||:||.:|:..||...|:.|||||||
Mouse    93 GPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGLFLSSGDKWSRHRRLLTPAFHF 157

  Fly   154 KVLQSFLIIFKEECNKLVKVLH-------QSVNMELELNQVIPQFTLNNVCETALGVKLDDLSEG 211
            .:|:.::.||    |:.|.::|       ...:..||:.:.|...||:::.:...|...:.....
Mouse   158 DILKPYVKIF----NQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQESP 218

  Fly   212 IRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSNQL 276
            ..|..:|..:..::.:|....|.:....::...|.|:......:.|.|:..:|.:||....|.
Mouse   219 SEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIRERRHTLSSQ-- 281

  Fly   277 GQEDEFGK-KQRYAMLD----TLLAAEADG-QIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLA 335
             ..|||.| |.:...||    .|||.:..| ::..:.|..|.:||||.|:|||::.|.:.|..||
Mouse   282 -NHDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLA 345

  Fly   336 LHEDVQKKCYEEIKYLPDDS-------DDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEE 393
            .|.:.|::|.:|::.|..|.       ||::     :|.::...|||||||...|..:.|||..:
Mouse   346 RHPEYQERCRQEVQELLRDREPEEIEWDDLA-----QLPFLTMCIKESLRLHSPVIDLLRRCTRD 405

  Fly   394 GVV-NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIG 457
            .|: :|.::||.....|.::.|..:...:.:|:::.|.||.|||...|.|.||:|||||.|||||
Mouse   406 IVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENPQKRSPLAFIPFSAGPRNCIG 470

  Fly   458 QKFAILEIKVLLAAVIRNFKILPVTLLDD----------LTFENGIVLRTK 498
            |.||:.|:||.||..:..|:|||    ||          |..|.|:.||.:
Mouse   471 QTFAMSEMKVALALTLLRFRILP----DDKEPRRKPEIILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	144/475 (30%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	144/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850