DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	145/523 - (27%)
Similarity:	242/523 - (46%)	Gaps:	71/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESIFNFMRDASAKAKGRNYLWY 90
            ||.....|.|:|....|         |.:..|..:..::....|.: ..:.:.....:..:.:|.
  Rat    38 TYSFCENCSRLRCFPQS---------PKRNWFLGHLGVIQSNEEGM-QLVTEMGQTFRDVHLIWL 92

  Fly    91 FFHAPMYNIVRAEEAEEILQSSKLITKN--MIYELLKPFLGEGLLISTDQKWHSRRKALTPAFHF 153
            ...:|:..:|.......:||:..|:...  .....|||:||:||.:|:..||...|:.|||||||
  Rat    93 GPVSPVLRLVDPAFVAPLLQAPALVAPKDPTFLHFLKPWLGDGLFLSSGDKWSRHRRLLTPAFHF 157

  Fly   154 KVLQSFLIIFKEECNKLVKVLHQSVNM--------------ELELNQVIPQFTLNNVCETALGVK 204
            .:|:.:           ||..:||||:              .||:.:.|...||:::.:...|..
  Rat   158 DILKPY-----------VKTFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLFGFD 211

  Fly   205 LDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRS 269
            .:.......|..:...:..:.::|....|.|....::...|.::......:.|.|:..:|.:||.
  Rat   212 SNCQESPSEYISATLELSSLTRKRSYKLFLYLDFLYYRTADGQRFRKACDLVHSFTDAVIRERRR 276

  Fly   270 LFKSNQLGQEDEF------GKKQRYAMLDTLLAA--EADGQIDHQGICDEVNTFMFEGYDTTSTC 326
            |..|..:   |||      .|.:....:|.||.|  |...::..:.|..|.:||||.|:|||::.
  Rat   277 LLSSQGV---DEFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASA 338

  Fly   327 LIFTLLMLALHEDVQKKCYEEI-KYLPD-DSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRR 389
            |.:.|..||.|.:.|::|.:|: :.|.| :.::|......:|.::...|||||||.|....:.||
  Rat   339 LSWILYNLASHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPAVDLLRR 403

  Fly   390 CVEEGVV-NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQR 453
            |.::.|: :|.::||.....|.::.|..:...:.:|:::.|.||.|||...|.|.:|:|||||.|
  Rat   404 CTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENRQKRSPLSFIPFSAGPR 468

  Fly   454 NCIGQKFAILEIKVLLAAVIRNFKILPVTLLDD----------LTFENGIVLRTKQNIKVKLVHR 508
            |||||.||:.|:||.:...:..|:.||    ||          |..|.|:.||      |:|:.|
  Rat   469 NCIGQTFAMNEVKVAVGLTLLRFRFLP----DDKEPRRKPELILRAEGGLWLR------VELLSR 523

  Fly   509 ENK 511
            :.:
  Rat   524 DTQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	136/484 (28%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	131/461 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850