DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	462	Identity:	127/462 - (27%)
Similarity:	217/462 - (46%)	Gaps:	51/462 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 FTSESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEIL--QSSKLITKNMIYELLKP-- 126
            |....::||.|:.:.| .|..:..|....||..|:..:..:.:|  :...:.|..|   .|.|
Human    52 FYLRGLWNFDRECNEK-YGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM---PLGPMG 112

  Fly   127 FLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSV--NMELELNQVIP 189
            ||...|..:.|::|...|..|:|||.....:..:.|..:..:.||:.|.|..  :..:.|.....
Human   113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFG 177

  Fly   190 QFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYF-FL--------FGD 245
            .:|::.:..|..||.||.|:.  .....:..::::::....:||...|..| ||        .|.
Human   178 AYTMDVITGTLFGVNLDSLNN--PQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

  Fly   246 YRKQVNNLKIAHEFSSNIIEK-RRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQIDHQGIC 309
            :.|.|.:      |..|.||: :.|..|..|..:.|.|.:     |:|:..:.|..   .|:.:.
Human   241 FPKDVTH------FLKNSIERMKESRLKDKQKHRVDFFQQ-----MIDSQNSKETK---SHKALS 291

  Fly   310 D-----EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQFNELVYM 369
            |     :....:|..||||||.|.|.:..||.|.|||:|..|||..:..:...::.....::.|:
Human   292 DLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYL 356

  Fly   370 ECVIKESLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPD-RFF 433
            :.|:.|:|||||.|..:.|.|.::..:||:.:||...:.:.:|.:..|.::::.|:.|.|: ||.
Human   357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421

  Fly   434 PENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILP-----VTL-LDDLTF--- 489
            .:|..:...:.::||.||.|||||.:||:..||:.:...::||...|     :.| ||:|..
Human   422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQP 486

  Fly   490 ENGIVLR 496
            |..|||:
Human   487 EKPIVLK 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	127/462 (27%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	127/462 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910