DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	446	Identity:	137/446 - (30%)
Similarity:	230/446 - (51%)	Gaps:	53/446 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 LWYFFHAPMYNIVRAEEAEEILQSSKLIT-KNMI-YELLKPFLGEGLLISTDQKWHSRRKALTPA 150
            :|.....|:..:..::....||.:|..:. |::| |.:|||:||:|||:|...||...|:.||||
Mouse    90 MWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPA 154

  Fly   151 FHFKVLQSFLIIFKEECNKLVKVLH-------QSVNMELELNQVIPQFTLNNVCETALGVKLDDL 208
            |||.:|:.::.||.:..|    ::|       ...:..|::.:.:...||:::.:.......:..
Mouse   155 FHFNILKPYVKIFNDSTN----IMHAKWQRLISDGSARLDMFEHVSLMTLDSLQKCVFSFDSNCQ 215

  Fly   209 SEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGD---YRKQVNNLKIAHEFSSNIIEKRRSL 270
            .:...|..:|..:..::.:|...|..:..:.:.|..|   :||..|   :.|||:..:|.:|...
Mouse   216 EKSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKACN---VVHEFTDAVIRERHRT 277

  Fly   271 FKSNQLGQEDEFGKKQRYAMLD----TLLAAEADG-QIDHQGICDEVNTFMFEGYDTTSTCLIFT 330
            ....  |.:|....|.:...||    .||:.:.|| ::..:.|..|.:||||||:|||::.|.:.
Mouse   278 LPDQ--GLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWI 340

  Fly   331 LLMLALHEDVQKKCYEEIKYL-----PDDS--DDISVFQFNELVYMECVIKESLRLFPSVPFIGR 388
            |..||.|.:.|::|.:|::.|     |::.  ||::     :|.::...|||||||.|.|..|.|
Mouse   341 LYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLA-----QLPFLTMCIKESLRLHPPVTVISR 400

  Fly   389 RCVEEGVV-NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQ 452
            .|.::.:: :|..:||.....|.::.|..:...:.:|:::.|.||.|||..:..|.||:|||||.
Mouse   401 CCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGP 465

  Fly   453 RNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDD----------LTFENGIVLRTK 498
            ||||||.||:.|:||.||..:..|::||    ||          |..|.|:.||.:
Mouse   466 RNCIGQTFAMSEMKVALALTLLRFRLLP----DDKEPRRQPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	137/446 (31%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	134/438 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850