Protein Alignment Cyp4ac2 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 107/529 - (20%)
• Similarity: 200/529 - (37%)
• Gaps: 144/529 - (27%)

  Fly     6 LFAAPLVIFIFRKLW-----AHLNRTYFILSLCKRIRTEDGS------------LLESKIYVAPS 53
            |.:..|::.:.::||     |..:::      || :....||            ||:...:.:..
Human    19 LVSVTLLLAVSQQLWQLRWAATRDKS------CK-LPIPKGSMGFPLIGETGHWLLQGSGFQSSR 76

  Fly    54 KTRFGNNFDLVNFTSESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKN 118
            :.::||.|                 .....||         |:..:..||...:||
Human    77 REKYGNVF-----------------KTHLLGR---------PLIRVTGAENVRKIL--------- 106

  Fly   119 MIYELLKPFLGEGLLISTDQKW---------------------HSRRKALTPAFHFKVLQSFLII 162
                     :||..|:||:  |                     .::||..:..|..:.|:|:|
Human   107 ---------MGEHHLVSTE--WPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYL-- 158

  Fly   163 FKEECNKLVKVLHQSVNM------ELELNQVIPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAI 221
                 .|:..|:..::..      .:.:.|...:.|........||..:.:        :.:..:
Human   159 -----PKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPE--------EDLGHL 210

  Fly   222 EEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEK--RRSLFKSNQLGQEDEFGK 284
            .||.||.:.|.|  ::.....|..||:.:.        :..|::|  .:::.:..|..|    ||
Human   211 FEVYQQFVDNVF--SLPVDLPFSGYRRGIQ--------ARQILQKGLEKAIREKLQCTQ----GK 261

  Fly   285 KQRYAMLDTLL--AAEADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEE 347
            ....| ||.|:  :.|...::..|.:.|.....:|..|.||::.....::.|..|..|.:|..:|
Human   262 DYLDA-LDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDE 325

  Fly   348 IKY--------LPDDSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVVNGLIMPKN 404
            ::.        .|.:. .:.:...:.|.|::|||||.:|||..:....|..::...::|..:||.
Human   326 LRAHGILHSGGCPCEG-TLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKG 389

  Fly   405 TQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRH-PFAFVPFSAGQRNCIGQKFAILEIKVL 468
            ..:...:.:....|..|.:..:|.||||....:.::. .|.::||..|.|.|:|:..|.|.:|||
Human   390 WSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVL 454

  Fly   469 ---LAAVIR 474
               ||:..|
Human   455 AVELASTSR 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	CYP4	84..503	CDD:410721	93/434 (21%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	98/481 (20%)