DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	437	Identity:	131/437 - (29%)
Similarity:	226/437 - (51%)	Gaps:	44/437 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 YFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKWHSRRKALTPAFHFK 154
            :|:.:..|.||...:..:::........|.:|.||.|::|.|||:...|.|...|:.||||||:.
  Rat    88 WFWGSKAYLIVYDPDYMKVILGRSDPKANGVYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYD 152

  Fly   155 VLQSFLIIFKEECNKLVKVLHQSVNME--LELNQVIPQFTLNNVCETAL----GVKLDDLSEGIR 213
            :|:.::....:....::....|....:  :|:.|.|...||:.|.:.|.    .|::|...:.
  Rat   153 ILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISLMTLDTVMKCAFSHNGSVQVDGNYKS-- 215

  Fly   214 YRQSIHAIEEVMQQRLCNPFFYN-IVYFF-----LFGDYRKQVNNLKIAHEFSSNIIEKRRSLFK 272
            |.|:|..:.::...|:.|.|..| .:|.|     ||.      ...::||:.:..:|:.|:...:
  Rat   216 YIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFN------RACQLAHDHTDGVIKLRKDQLQ 274

  Fly   273 SNQLGQEDEFGKKQRYAMLDTLLAA--EADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLA 335
            :  .|:.::..||:|...||.||.|  |....:..:.:..||:||||||:|||::.:.:....||
  Rat   275 N--AGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALA 337

  Fly   336 LHEDVQKKCYEEIKYLPDDSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVV--NG 398
            .|.:.|::|.||::.:..|...|:....:::.|....|||:|||:|.||.|.|. :...|.  :|
  Rat   338 THPEHQQRCREEVQSVLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRE-LSTSVTFPDG 401

  Fly   399 LIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAIL 463
            ..:||..|:.:.:|.:..:.:.:.||::|.|.||.|::.  ||..:|:|||.|.|||||::||:.
  Rat   402 RSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSP--RHSHSFLPFSGGARNCIGKQFAMS 464

  Fly   464 EIKVLLAAVIRNFKILPVTLLDD-----------LTFENGIVLRTKQ 499
            |:||::|..:..|::||    |.           |..:|||.|..|:
  Rat   465 EMKVIVALTLLRFELLP----DPTKVPIPLPRLVLKSKNGIYLYLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	131/437 (30%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	129/431 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850