DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac2 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	533	Identity:	144/533 - (27%)
Similarity:	254/533 - (47%)	Gaps:	79/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEVLFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNF---DL- 63
            |:|:....|::.:.:....:|:|.:.|.|            |:......|.:..|||..   ||
Mouse    19 LQVVSLLGLLLLLLKSAQYYLHRQWLIKS------------LQQFPPAPPPQWLFGNTLKDQDLQ 71

  Fly    64 ------VNFTSESIFNFMRDASAKAKGRNYLW-----YFFHAPMY-NIVRAEEAEEILQSSKLIT 116
                  ..|.|..:              .:||     ...:.|.| .::......::::|
Mouse    72 QILLCVEKFPSTYV--------------RWLWGNHARVVIYDPDYMKVILGRSDPKVVRS----- 117

  Fly   117 KNMIYELLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME 181
                |....|::|.|||:...:||...|:.||||||:.:|:.::.|..:..:.::....|.|:.:
Mouse   118 ----YSFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQD 178

  Fly   182 --LELNQVIPQFTLNNVCETAL----GVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYF 240
              ||:.|.|...|:..:.:.|.    .|:|:|......|.:::..:..::..|:.|.|..|...:
Mouse   179 CPLEIYQDISLMTMETMMKCAFSYQGSVQLEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIY 243

  Fly   241 FLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQE---DEFGKKQRYAMLDTLLAAEA-DG 301
            .|..:.|...:..:|||:.:..:|..|::     ||..|   ::|.||:|...||.||.|:. ||
Mouse   244 SLSSNGRSFYHACQIAHKHTERVIRMRKA-----QLQNEAELEKFRKKKRLDFLDILLFAQTEDG 303

  Fly   302 Q-IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQFNE 365
            : :..:.:..|::||||||::||::.:.:....||.|.:.|::|.||:|.:..:...:::...::
Mouse   304 KSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVTLNHLDQ 368

  Fly   366 LVYMECVIKESLRLFPSVPFIGRRCVEEGVV--NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQ 428
            :.|....|||:|||:|.:|...|. :...|.  :|..:||...:.:..|.:..:.|...|.::|.
Mouse   369 MPYTTMCIKEALRLYPPIPGASRE-LSSPVTFPDGCSLPKGFLVTLSFYGLHHNPRLRPNAEVFD 432

  Fly   429 PDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILP----VTLLDD--- 486
            |.||.|  ...|...||:|||||.|||||::|.:.|:||.:|..:..|::||    |.:|..
Mouse   433 PSRFAP--GAPRQTHAFLPFSAGTRNCIGKQFTMNELKVAVALTLLRFELLPDPTRVPILVSKIV 495

  Fly   487 LTFENGIVLRTKQ 499
            |..:|||.|.||:
Mouse   496 LKSKNGIYLHTKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	135/479 (28%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	132/475 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850