DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac2 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	132/528 - (25%)
Similarity:	233/528 - (44%)	Gaps:	62/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEVLFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFT 67
            :.:|.|...:.:|: .||:. .|.||::               .||   |...    ...::..:
  Fly     4 INLLLAVGALFWIY-FLWSR-RRLYFLM---------------LKI---PGPI----GLPILGSS 44

  Fly    68 SESIFNFMRDASAKAK-----GRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNM-IYELLKP 126
            .|:|..:.|..|.:.|     |...|.:....|.......:..|:|..|.....|:. |...:..
  Fly    45 LENIITYKRKLSFRTKYLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITS 109

  Fly   127 FLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNM-ELELNQVIPQ 190
            .:|.|||...|..|..|||...|:|...:|.||..||..|...|:.:|...|:. |:::...:.:
  Fly   110 CMGNGLLGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLR 174

  Fly   191 FTLNNVCETALG--VKLDDLSEGIRYRQSIHAIEEVMQQRLCN---PFFYNIVYFFLFGDYRKQV 250
            ::.....:|.:|  ||.|   |..:....:.:.|.::.....|   |...|.:...:.|..:.:.
  Fly   175 WSFKIAAQTTMGSEVKHD---EHFKNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRA 236

  Fly   251 NNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQIDHQGICDEVNTF 315
            :|.....:...|::.|     |.|.|.:.|  ...:...:::..:.....|.|.:..:..|....
  Fly   237 DNFSRIQKMLDNVVNK-----KVNPLPKTD--SDPESNIVINRAMELYRKGDITYMDVKSECCIM 294

  Fly   316 MFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVF--QFNELVYMECVIKESLR 378
            :..||||::..:...|.:||.|.:.|:..:||:..:..|:....:.  ...:|.|:|.||||:||
  Fly   295 IAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLR 359

  Fly   379 LFPSVPFIGRRCVEE-GVVNGLIMPKNTQINIHLYEIMRDARHFSNPKM-------FQPDRFFPE 435
            |.|::|...|....: .:.||:::||...|.|.::...|      ||::       |.||.|..|
  Fly   360 LIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHR------NPEVWGPDADNFNPDNFLAE 418

  Fly   436 NTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQN 500
            |...:||:|::||:.|:|||||.|:|::..|..|..::||:||...||..||.:.:.:.::..:.
  Fly   419 NMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMKLAEY 483

  Fly   501 IKVKLVHR 508
            .::||..|
  Fly   484 PRLKLQRR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	118/469 (25%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	115/449 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	4	3.960