DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp313a5

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	118/509 - (23%)
Similarity:	224/509 - (44%)	Gaps:	58/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRF---GNNFDLVNFT 67
            :|.|..:|.....||:  .|.::|:.|              |:   |....|   |..|:.:...
  Fly     6 IFEAFAIILCVYFLWS--RRRFYIMML--------------KL---PGPMGFPFIGLAFEYIRLK 51

  Fly    68 SESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYE-LLKPFLGEG 131
            .:.   .:|....|..|:..|.:....|:......:..|:|..|.....::.:.: .:...||.|
  Fly    52 RKI---RLRTILFKIYGKTVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISSCLGLG 113

  Fly   132 LLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQ-----SVNMELELN----QV 187
            ||...:..|:.|||.|.|:|....:.||:.:...|.|.||.:|.:     .:|:..|||    ::
  Fly   114 LLTLKNNHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPELNKWSFKI 178

  Fly   188 IPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNN 252
            ..|.|:.:........:..:|.|..:...::..|..||      |:..|.....||...::::..
  Fly   179 AAQITMGDEVRNQANYQNGNLLESYKALNNLIPIGVVM------PWLRNKYLGKLFSYEKRRLEA 237

  Fly   253 LKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQIDHQGICDEVNTFMF 317
            ...::.|..:||:|:        |...|...:.   |::|.:|.....|::.:..:..|.:..:|
  Fly   238 ATQSNAFIKDIIDKK--------LSSTDNSSEP---ALIDRILNLVRIGELSYDDVMGEFSNIIF 291

  Fly   318 EGYDTTSTCLIFTLLMLALHEDVQKKCYEEI-KYLPDDSD-DISVFQFNELVYMECVIKESLRLF 380
            ...||.|..:...|:::|:....|...:||: :..|...: :.|.....:||.::.|:.|::||.
  Fly   292 AASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHETMRLI 356

  Fly   381 PSVPFIGRRCVEE-GVVNGLIMPKNTQINIHLYEIMRDARHFSNPK--MFQPDRFFPENTVNRHP 442
            |:||.:.|:.... .:.||..:|:...:.|.::...|: :....|:  .|.||.|.|||...|.|
  Fly   357 PAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRN-KDIWGPQANAFNPDNFLPENKRARPP 420

  Fly   443 FAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLR 496
            ::::|||.|::.|:|.|.:::..|:.||.::||:.:....|..||.|.:...::
  Fly   421 YSYLPFSKGKKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRFIDNTTMK 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	108/458 (24%)
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	105/445 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960