Protein Alignment Cyp4ac2 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 146/503 - (29%)
• Similarity: 247/503 - (49%)
• Gaps: 55/503 - (10%)

  Fly     8 AAP-LVIFIFRKLWAHLNR----TYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFT 67
            |:| |::.:....|. |.|    ||.....|.|:|.         ....|.:..|..:..|::.:
Human    16 ASPWLLLLLVGASWL-LARILAWTYTFYDNCCRLRC---------FPQPPKRNWFLGHLGLIHSS 70

  Fly    68 SESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEI----LQSSKLITKNMI-YELLKPF 127
            .|.:  ....:.|...|....|:.  .|.:.|||......|    ...:.::.|:.: |..|||:
Human    71 EEGL--LYTQSLACTFGDMCCWWV--GPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPW 131

  Fly   128 LGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNM-------ELELN 185
            ||:|||:|..:||...|:.|||||||.:|:.::.||.|..|    ::|....:       .|::.
Human   132 LGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVN----IMHAKWQLLASEGSARLDMF 192

  Fly   186 QVIPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQV 250
            :.|...||:::.:...........:...|..:|..:..::.:|......|....::|..|.::..
Human   193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFR 257

  Fly   251 NNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLD----TLLAAEADG-QIDHQGICD 310
            ...::.|:|:..:|::||....|.  |.:|....|.:...||    .||:.:.|| ::..:.|..
Human   258 RACRLVHDFTDAVIQERRRTLPSQ--GVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRA 320

  Fly   311 EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDS-------DDISVFQFNELVY 368
            |.:||||||:|||::.|.:.|..||.|.:.|::|.:|::.|..|.       ||::     :|.:
Human   321 EADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA-----QLPF 380

  Fly   369 MECVIKESLRLFPSVPFIGRRCVEEGVV-NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRF 432
            :...|||||||.|.||.:.|.|.::.|: :|.::||.....|.::....:...:.:|:::.|.||
Human   381 LTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445

  Fly   433 FPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILP 480
            .|:|...|.|.||:|||||.||||||.||:.|:||:|...:..|::||
Human   446 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	CYP4	84..503	CDD:410721	130/422 (31%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	131/435 (30%)