DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	132/458 - (28%)
Similarity:	239/458 - (52%)	Gaps:	49/458 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SESIFNFMRDASAKAKGRNYLWYFFHAPMYNI-VRAEEAEEILQSSKLITKNMIYELLKPFLGEG 131
            :|.|...:.|..||      ||  ....:|.: ...::.:.:..:.:|:.|...|.:.:.:|.||
  Fly    62 TEMINEHLHDHRAK------LW--MGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEG 118

  Fly   132 LLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNM--ELELNQVIPQFTLN 194
            |..|..:||..|||.:.|||::.:::.|:.:|:::...|:..:.:....  :::..|:|..|||:
  Fly   119 LFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLD 183

  Fly   195 NVCETALGVKLDDLSEG-IRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHE 258
            .:|||||||.:...|.. ..|..::.:|..::.:||.|.|:.|...|.....|:::...:|..|.
  Fly   184 TICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHG 248

  Fly   259 FSSNIIEKRRSLFKSNQLGQEDEF--------GKKQRYAMLDTLLAAEA-DGQ-IDHQGICDEVN 313
            |:..||:||  :.:.||..:...:        |.|:....|||||.::. ||: :..:.|.:||:
  Fly   249 FTEGIIQKR--IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVD 311

  Fly   314 TFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYL--PDDSDDISVFQFNELVYMECVIKES 376
            |.:|.|:|.|:|.|.|.:..:.||.:.|::|.||:..:  .|.|:.||:.|..:|.::|..|||:
  Fly   312 TIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKET 376

  Fly   377 LRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRH 441
            ||::||.|...|:......:|...:||.:.:.|....:.|....|.:|.:|:|||:    .:...
  Fly   377 LRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRW----AIGAE 437

  Fly   442 P----FAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQNIK 502
            |    ..|:||.||.|:|:||::|::.:|::||.::|||...|:               .::.:|
  Fly   438 PKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPL---------------GERQVK 487

  Fly   503 VKL 505
            :||
  Fly   488 LKL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	130/456 (29%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	132/458 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460537
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.990