DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	121/484 - (25%)
Similarity:	209/484 - (43%)	Gaps:	71/484 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SIFNFMRDA------------SAKAKGRNYLW---YFFHAPMYN---IVRAEEAEEILQ-SSKLI 115
            :::|.:|.|            |.:|.||.::.   ...||.:..   :::....|:..| ||:..
  Fly    62 NVWNLLRGACCFGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFE 126

  Fly   116 TKNMIYELLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSV-- 178
            |.:...:.:.   .:.|..|..:.|....|...|.|....:::...:.:....||.:.:.|.:
  Fly   127 TTDPTCDTMG---SQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSG 188

  Fly   179 --NMELELNQVIPQFTLNNVCETALGVKLDDL-SEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYF 240
              :||||:.|:...||.:.:...|.|::...| :....:|:....:.:...:||.:.|   .::|
  Fly   189 RDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLF---TMFF 250

  Fly   241 FLFGDYRKQVNNLKIAHEFSSNII--EKRRSLFKSNQ--LGQEDEFGKKQRYAMLDTLL---AAE 298
            |           .:::|...:::.  |..|.:.||..  |.|..|.| :.|:.::|..|   ..|
  Fly   251 F-----------PRLSHRVGTHLYSEEYERFMRKSMDYVLSQRAESG-ENRHDLIDIFLQLKRTE 303

  Fly   299 ADGQIDHQG--ICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDD--IS 359
            ....|.|:.  ...:....:..|:||:|:.:.|.|..||.:..:|.:...|::.....|.|  :|
  Fly   304 PAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLS 368

  Fly   360 VFQFNELVYMECVIKESLRLFPSVPFIGRRC-----VEEGVVNG---LIMPKNTQINIHLYEIMR 416
            ......|||:..|:.|.|||:|...|:.|.|     .:....||   ..:...|.:.|.:..|.|
  Fly   369 CDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHR 433

  Fly   417 DARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKI--- 478
            ||:::.||::|.|:||..|.....||..::||.||.|.|||.....|||||.|..::.:|::
  Fly   434 DAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVC 498

  Fly   479 ---LPVTLLDD----LTFENGIVLRTKQN 500
               ||....|.    ||..||..||..:|
  Fly   499 ERTLPEMRFDPKAFVLTAHNGTYLRFVKN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	121/484 (25%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	107/441 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010