DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	178/518 - (34%)
Similarity:	296/518 - (57%)	Gaps:	51/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTR---FGNNFDLVNFTSESIF 72
            ||:.:...|...|..:.|.|:| |.:|..    |:.   |.||.:|   .|..:.:.:|..:::.
  Fly     2 LVVLLVALLVTRLVASLFRLAL-KELRHP----LQG---VVPSVSRVPLLGAAWQMRSFQPDNLH 58

  Fly    73 NFMRDASAKAKGRNYLWYFF-HAPMYNIVRAE--EAEEILQSSKLITKNMIYELLKPFLGEGLLI 134
            :...: ..|..||:::.... |..|   |.||  ..:.:||....:.|..:|..|:.:||:|||:
  Fly    59 DKFAE-YVKRFGRSFMGTVLGHVVM---VTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLL 119

  Fly   135 STDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNMELELNQVIPQF---TLNNV 196
            |..::||:.||.:||.|||.:|:.|:.:|..:.:.||:.| ::::...|:..:.|..   .|:.:
  Fly   120 SRGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERL-RTLSYGNEVVNIYPLVGLAALDII 183

  Fly   197 CETALGVKLDDLSEGIRYRQSIHAIEE---VMQQRLCNPFFYNIVYFFLF-----GDYRKQVNNL 253
            .|||:||.:|  ::|.. .:.:||:::   ::..|...|   ::::..||     ..:|||...:
  Fly   184 TETAMGVNVD--AQGAD-SEVVHAVKDLTNILATRFMRP---HLLFPHLFRLCWPSGFRKQQAGV 242

  Fly   254 KIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQR-YAMLDTLLAAEADGQ-IDHQGICDEVNTFM 316
            ...|||::.|||:||.|     |.:|....|..: :|:|||||.|..||| :..:.|.||||||:
  Fly   243 ICLHEFTNGIIEQRRRL-----LAREANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFI 302

  Fly   317 FEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIK--YLPDDSDDISVFQFNELVYMECVIKESLRL 379
            |||:|||::.:.|.|.:|:.||.||:|.:||::  |..|....:.:..|..|.|:.||:||||||
  Fly   303 FEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRL 367

  Fly   380 FPSVPFIGRRCVEEGVV--NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHP 442
            :|.:|.:. ||:|:.:|  .|.| |..|.:.:.|::::||...|::|.:|||:|...|......|
  Fly   368 YPPIPAVA-RCLEKDLVIDEGYI-PVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSP 430

  Fly   443 FAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQNIKVKL 505
            ::::|||||.|||||||||:||:|.::..|||::::||:..  |:.....||||:|..:.|.|
  Fly   431 YSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGA--DVEPSIKIVLRSKSGVNVGL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	163/467 (35%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	165/470 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460501
Domainoid	1	1.000	160	1.000	Domainoid score	I1269
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000