DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4d1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	172/527 - (32%)
Similarity:	282/527 - (53%)	Gaps:	81/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GSLLESKIYVA--PSKTRFGNNFDLVNFTS-----------------------ESIFNFMRDASA 80
            |::|.|.::|.  ....:|....||:::..                       :.||.||...|
  Fly     6 GAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYS- 69

  Fly    81 KAKGRNYLWYFFHAPMYNIV--RAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKWHSR 143
                ::.:...:..|..|::  ..::.|.:|.:.:...|...|:.|:|:|.||||:|..:|||.|
  Fly    70 ----KDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKR 130

  Fly   144 RKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME----------LELNQVIPQFTLNNVCE 198
            ||.:|||||||:|..|:.:|::....|::      |||          ..|...|...|::.:||
  Fly   131 RKIITPAFHFKILDQFVEVFEKGSRDLLR------NMEQDRLKHGDSGFSLYDWINLCTMDTICE 189

  Fly   199 TALGVKLDDLSEG-IRYRQSIHAIEEVMQQRLCNPFFYNIVY-----FFLFGDYRKQVNNLKIAH 257
            ||:||.::..|.. ..|.|::..|..|:.:|:     :||:|     :.|....|.:...|.:.|
  Fly   190 TAMGVSINAQSNADSEYVQAVKTISMVLHKRM-----FNILYRFDLTYMLTPLARAEKKALNVLH 249

  Fly   258 EFSSNII-EKRRSLFK--SNQLGQED--EFGKKQRYAMLDTLLAAEADGQ-IDHQGICDEVNTFM 316
            :|:..|| ::|..|.:  |:|....|  :.|.|::.|.||.||.:..|.: :.:..|.:||:|||
  Fly   250 QFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFM 314

  Fly   317 FEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYL--PDDSDDISVFQFNELVYMECVIKESLRL 379
            |||:||||:.|:|....:|.|.:.||||:|||:.:  .|.|..:|....|:|.|::..:||:||:
  Fly   315 FEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRM 379

  Fly   380 FPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNR-HPF 443
            :||||.:||:.:|:..:||.::|..|.|.|....:.|....||.|.:|:|:||....|..: :|:
  Fly   380 YPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPY 444

  Fly   444 AFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKI-------LPVTLLDDLTFENGIVLRTKQNI 501
            |::|||||.|||||||||:||||.::|.|:|::::       .|..|:.:|      :||||:.:
  Fly   445 AYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAEL------ILRTKEPL 503

  Fly   502 KVKLVHR 508
            ..|:..|
  Fly   504 MFKVRER 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	166/504 (33%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	163/493 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460507
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000