DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	139/459 - (30%)
Similarity:	232/459 - (50%)	Gaps:	43/459 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 NYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKWHSRRKALTPA 150
            |.|..|...|       .:.|.||...:.:||...|...||:.|:|||||....|...||.:.|.
  Fly   101 NVLLVFLTNP-------SDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPT 158

  Fly   151 FHFKVLQSFLIIFKEECNKLVKVLHQSVNMELELNQVIPQFTLNNVCETALGV-KLDDLSEGIRY 214
            ||..:|:||:..|.:....:|..:........:::..:.|.|::.:..||:|| ||.:.::...|
  Fly   159 FHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEY 223

  Fly   215 RQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNL---------KIAHEFSSNIIEKRRSL 270
            .|::..:.:::.:|... ..|.:...:.|...|::.:.:         |:..:...|..|:.|::
  Fly   224 AQAVVDMCDIIHKRQVK-LLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAI 287

  Fly   271 FK-----------SNQLG--------QEDEFGKKQRYAMLDTL--LAAEADGQIDHQGICDEVNT 314
            .:           |.:.|        .|::.|.|:|.|:||.:  :|...|.:.:.:.|.|||||
  Fly   288 VEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNT 352

  Fly   315 FMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDS--DDISVFQFNELVYMECVIKESL 377
            .||||:||||....|.|.|:.:|:|:|.|.:.|.|.:..|:  .|.:.....|:.|:|.||.|:|
  Fly   353 IMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETL 417

  Fly   378 RLFPSVPFIGRRC-VEEGVVNG-LIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNR 440
            ||:|.||.|.||. .:..:.:| ..:||.|.:.:..|.:.|....:.||..|.||.|.||...||
  Fly   418 RLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANR 482

  Fly   441 HPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQNIKVKL 505
            |.::|:|||||.|:|:|:|:|:|::||||:.::||:.:.......|...:..|:|:.:....|.|
  Fly   483 HYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFNVSL 547

  Fly   506 VHRE 509
            ..|:
  Fly   548 EKRQ 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	137/453 (30%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	132/424 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070