DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	141/441 - (31%)
Similarity:	219/441 - (49%)	Gaps:	46/441 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 WYFFHAPMYNIVRAEEAEEILQSSKLIT--KNMIYELLKPFLGEGLLISTDQKWHSRRKALTPAF 151
            |.....|:..:|..:..:.:|.:|..|.  ....|..|||:||:|||||...||...|:.|||||
  Rat    99 WVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLISKGNKWSRHRRLLTPAF 163

  Fly   152 HFKVLQSFLIIFKEECNKLVKVLHQSVNMEL--------ELNQVIPQFTLNNVCETALGVKLDDL 208
            ||.:|:.::.||    |:.|.::|......|        ::.:.:...||:::.:.......|..
  Rat   164 HFDILKPYMKIF----NQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSLQKCVFSYSSDCQ 224

  Fly   209 SEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKS 273
            .:...|..||..:..::.:|......|....::|..|.|:........|.|::.:|::||...:
  Rat   225 EKLSDYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQACDTVHNFTTEVIQQRRRALR- 288

  Fly   274 NQLGQEDEFGKKQRYAM--LDTLLAA--EADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLML 334
             :||.|.....||...:  :|.||.|  |...::..:.|..|.:||||||:||||:.|.:.|..|
  Rat   289 -ELGAEAWLKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAEADTFMFEGHDTTSSGLSWALFNL 352

  Fly   335 ALHEDVQKKCYEEIKYLPD-------DSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVE 392
            |.:.:.|.||.|||:.:..       |.||::...|..:    | ||||||.||.|..|.|||.|
  Rat   353 AKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTM----C-IKESLRQFPPVTLISRRCTE 412

  Fly   393 E-GVVNGLIMPKNTQINIHLYEIMRDARHFSNP------KMFQPDRFFPENTVNRHPFAFVPFSA 450
            : .:.:|.|:||.....:.:|     ..|: ||      |::.|.||.|:....|.|.|||||||
  Rat   413 DIKLPDGRIIPKGIICLVSIY-----GTHY-NPLVWPDSKVYNPYRFDPDIPQQRSPLAFVPFSA 471

  Fly   451 GQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQNI 501
            |.||||||.||:.|::|::|..:..|: |.|.....:..:..::|||:..:
  Rat   472 GPRNCIGQSFAMAEMRVVVALTLLRFR-LSVDRTRKVRRKPELILRTENGL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	141/441 (32%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	141/441 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850