DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	145/539 - (26%)
Similarity:	253/539 - (46%)	Gaps:	82/539 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLEVLFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVN 65
            :.|.::.|:.|:.:|       |.:.|.:....:|:|         :....|::.....:..|:.
  Rat    20 LLLLLVGASCLLAYI-------LPQVYAVFENSRRLR---------RFPQPPTRNWLFGHLGLIQ 68

  Fly    66 FTSE------SIFNFMRDASAKAKGRNYLWYFFHAPMYNIVR----AEEAEEILQSSKLITKNMI 120
            .:.|      |:....||...        |:.  .|.:.::|    |.....||..:.:..|:.:
  Rat    69 SSEEGLLYIQSLSRTFRDVCC--------WWV--GPWHPVIRIFHPAFIKPVILAPASVAPKDRV 123

  Fly   121 -YELLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLH-------QS 177
             |..|||:||:|||:||..||...|..|||||||.:|:.::.||.:..|    ::|       ..
  Rat   124 FYRFLKPWLGDGLLLSTGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTN----IMHAKWQRLASQ 184

  Fly   178 VNMELELNQVIPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFL 242
            .:..|::.:.|...||:::.:.......:...:...|..:|..:..::.:|..:...|..:::.|
  Rat   185 GSARLDMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSALVARRHQSLLLYVDLFYHL 249

  Fly   243 FGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLD----TLLAAEADGQ- 302
            ..|..:.....::.|:|:..:|.:||......  |.:|....|.:...||    .||:.:..|:
  Rat   250 TRDGMRFRKACRLVHDFTDAVIRERRRTLPDQ--GGDDALKAKAKAKTLDFIDVLLLSKDEHGEA 312

  Fly   303 IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDS-------DDISV 360
            :..:.|..|.:||||.|:|||::.|.:.|..||.|.:.|::|.:|::.|..|.       ||::
  Rat   313 LSDEDIRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLA- 376

  Fly   361 FQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVV-NGLIMPKNTQINIHLYEIMRDARHFSNP 424
                :|.::...|||||||.|....|.|.|.::.:: :|.::||.....|.::....:...:.:|
  Rat   377 ----QLPFLTMCIKESLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDP 437

  Fly   425 KMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDD--- 486
            :::.|.||..:|...|.|.||:|||||.||||||.||:.|:||.||..:..|::||    ||
  Rat   438 EVYNPFRFDADNGEGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLP----DDKEP 498

  Fly   487 -------LTFENGIVLRTK 498
                   |..|.|:.||.:
  Rat   499 RRKPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	136/483 (28%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	132/465 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850