DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	145/501 - (28%)
Similarity:	239/501 - (47%)	Gaps:	51/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESIFNFMRDASAKAKGRNYLWY 90
            ||.....|.|:|....|         |.:..|..:...:....|.: ..:.:.....:..:..|.
  Rat    38 TYSFCENCSRLRCFPQS---------PKRNWFLGHLGTIQSNEEGM-RLVTEMGQTFRDIHLCWL 92

  Fly    91 FFHAPMYNIVRAEEAEEILQSSKLIT-KNMIY-ELLKPFLGEGLLISTDQKWHSRRKALTPAFHF 153
            ....|:..:|.......:||:..|:. |:..: ..|||:||:||.:|:..||...|:.|||||||
  Rat    93 GPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFLKPWLGDGLFLSSGDKWSRHRRLLTPAFHF 157

  Fly   154 KVLQSFLIIFKEECNKLVKVLHQ-------SVNMELELNQVIPQFTLNNVCETALGVKLDDLSEG 211
            .:|:.::.||    |:.|.::|.       ..:..||:.:.|...||:::.:...|...:.....
  Rat   158 DILKPYVKIF----NQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLFGFDSNCQESP 218

  Fly   212 IRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSNQL 276
            ..|..:|..:..::.:|....|.|....::...|.|:......:.|.|:..:|.:||.|..|.
  Rat   219 SEYISAILELSSLIIKRSQQLFLYLDFLYYRTADGRRFRKACDLVHNFTDAVIRERRRLLSSQ-- 281

  Fly   277 GQEDEF------GKKQRYAMLDTLLAA--EADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLM 333
             ..|||      .|.:....:|.||.|  |...::..:.|..|.:||||.|:|||::.|.:.|..
  Rat   282 -GTDEFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYN 345

  Fly   334 LALHEDVQKKCYEEI-KYLPD-DSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVV 396
            ||.|.:.|::|.:|: :.|.| :.::|......:|.::...|||||||.|....:.|||.::.|:
  Rat   346 LARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPAIDLLRRCTQDIVL 410

  Fly   397 -NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKF 460
             :|.::||.....|.::.|..:...:.:|::|.|.||..||...|.|.:|:|||||.||||||.|
  Rat   411 PDGRVIPKGNICVISIFGIHHNPSVWPDPEVFDPFRFDSENRQKRSPLSFIPFSAGPRNCIGQTF 475

  Fly   461 AILEIKVLLAAVIRNFKILPVTLLDD----------LTFENGIVLR 496
            |:.|:||::|..:..|::||    ||          |..|.|:.||
  Rat   476 AMNEMKVVVALTLLRFRVLP----DDKEPRRKPEIILRAEGGLWLR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	138/470 (29%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	138/484 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850