DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac2 and Cyp4a12a

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_803125.2	Gene:	Cyp4a12a / 277753	MGIID:	88612	Length:	508	Species:	Mus musculus

Alignment Length:	535	Identity:	151/535 - (28%)
Similarity:	255/535 - (47%)	Gaps:	79/535 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLEVLFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNF----D 62
            :|:|.....|::.:|:....:|:|.:.:.|             ..:....||...||:..    |
Mouse    18 YLQVASVLSLLLLLFKTAQLYLHRQWLLSS-------------TQQFPSPPSHWLFGHKILKDQD 69

  Fly    63 LVNFTSESIFNFMRDASAKAKGRNYLW-----YFFHAPMYNIVRAEEAEEILQSSKLI------T 116
            |.:..:. |.||   .||..:   :||     ...:.|.|              .|||      .
Mouse    70 LQDILTR-IKNF---PSACPQ---WLWGSKVRIQVYDPDY--------------MKLILGRSDPK 113

  Fly   117 KNMIYELLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME 181
            .|..|..|.|::|.|||:...|.|...|:.||||||:.:|:.:..|..:....::....|.|..:
Mouse   114 ANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQD 178

  Fly   182 --LELNQVIPQFTLNNVCETAL----GVKLDDLSEGIRYRQSIHAIE---EVMQQRLCNPFFYNI 237
              ||:.:.|...||:.:.:.|.    .|:||.     :|:..|.|:|   :::..|:.|.|..|.
Mouse   179 STLEIFRHITLMTLDTIMKCAFSHEGSVQLDR-----KYKSYIQAVEDLNDLVFSRVRNIFHQND 238

  Fly   238 VYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQEDE---FGKKQRYAMLDTLLAAEA 299
            :.:.:..:..|..:..|:||:.:..:|:.||.     ||..|:|   ..||:|...||.||.|..
Mouse   239 IIYRVSSNGCKANSACKLAHDHTDQVIKSRRI-----QLQDEEELEKLKKKRRLDFLDILLFARM 298

  Fly   300 DG--QIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQ 362
            :.  .:..:.:..||:||||||:|||::.:.:....||.:.:.|::|.:||:.|..|...|:...
Mouse   299 ENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITWND 363

  Fly   363 FNELVYMECVIKESLRLFPSVPFIGRRCVEEGVV--NGLIMPKNTQINIHLYEIMRDARHFSNPK 425
            .:::.|....|||:||::|.||.:.|. :...|.  :|..:||...:.:..|.:..:...:.||:
Mouse   364 LDKMPYTTMCIKEALRIYPPVPSVSRE-LSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPE 427

  Fly   426 MFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFE 490
            :|.|.||.|.:  :||..:|:|||.|.|||||::||:.|:||.:|..:..|::||......:...
Mouse   428 VFDPSRFAPGS--SRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIP 490

  Fly   491 NGIVLRTKQNIKVKL 505
            . |||::|..|.:.|
Mouse   491 R-IVLKSKNGIHLHL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	141/478 (29%)
Cyp4a12a	NP_803125.2	p450	52..502	CDD:278495	143/484 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850