Protein Alignment Cyp4ac2 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 130/470 - (27%)
• Similarity: 228/470 - (48%)
• Gaps: 72/470 - (15%)

  Fly    89 WYFFHAPMYNIVRAEEAEEILQ------------------------SSKLITK-----NMIYELL 124
            |:..|.........|:.|||::                        :..|:::     ..:.:..
Human    53 WFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFS 117

  Fly   125 KPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNMELELNQVI- 188
            .|.||:||......||...|:.|||.|||.:|:::           ::|:..||.|.|:..:.|
Human   118 PPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY-----------IEVMAHSVKMMLDKWEKIC 171

  Fly   189 -PQFTLNNVCETALGVKLDDL--------------SEGIRYRQSIHAIEEVMQQRLCNPFFYNIV 238
             .|.|...|.|....:.||.:              |....|.::|..:.:::..||.:..:::.:
Human   172 STQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDI 236

  Fly   239 YFFLFGD-YRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYA-MLDTLLAA--EA 299
            .|.|... ||.|..: ::.::::..||::|:   ||.|.|.:.:...|::|. .||.:|:|  |:
Human   237 IFKLSPQGYRFQKLS-RVLNQYTDTIIQERK---KSLQAGVKQDNTPKRKYQDFLDIVLSAKDES 297

  Fly   300 DGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQFN 364
            ........:..||:||:..|:||.:..:.:.|..|||:.:.|::|.||::.:..|...|:..|..
Human   298 GSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLG 362

  Fly   365 ELVYMECVIKESLRLFPSVPFIGRRCVEE-GVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQ 428
            |:.|....|||:.||.|:||.|.|...:. ...:|..:|....:.:.::.:..:...:.|||:|.
Human   363 EMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFD 427

  Fly   429 PDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLD---DLTFE 490
            |.||..||:..|||:|::|||||.||||||:||::|:||.:|.::.:|::.|    |   .|||.
Human   428 PLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP----DPTRPLTFP 488

  Fly   491 NGIVLRTKQNIKVKL 505
            |..:|:.|..:.:.|
Human   489 NHFILKPKNGMYLHL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	CYP4	84..503	CDD:410721	129/466 (28%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	127/454 (28%)
		heme binding region	447..460		10/12 (83%)