DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and erg11

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_592990.1	Gene:	erg11 / 2542599	PomBaseID:	SPAC13A11.02c	Length:	495	Species:	Schizosaccharomyces pombe

Alignment Length:	483	Identity:	84/483 - (17%)
Similarity:	187/483 - (38%)	Gaps:	123/483 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 FDLVNFTSESI------FNFMRDASAK-------------------AKGRNYLWYFFHAPMYNIV 100
            |..:.|...::      :.|.|:..||                   .:|.::|   |:..:.::
pombe    37 FHWIPFVGSAVAYGMDPYVFFRECRAKYGDVFTFVCMGRKMTAFLGVQGNDFL---FNGKLADL- 97

  Fly   101 RAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKE 165
            .||||...| ::.:..|:::|::            .:..:...:|.:.....|...:|::.:...
pombe    98 NAEEAYSHL-TTPVFGKDVVYDI------------PNHVFMEHKKFIKSGLGFSQFRSYVPLILN 149

  Fly   166 ECNKLVKVLHQSVNMEL--------ELNQVIPQFTLNNVCETALGVKL------------DDLSE 210
            |.:..:     |.:.:.        :|.:.:|..|:.....|..|.::            .||.:
pombe   150 EMDAFL-----STSPDFGPGKEGVADLLKTMPVMTIYTASRTLQGAEVRKGFDAGFADLYHDLDQ 209

  Fly   211 GIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFL-FGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSN 274
            |.                  :|  .|.|:.:| ....|::....||..:....||:.|||  .:.
pombe   210 GF------------------SP--VNFVFPWLPLPRNRRRDRAHKIMQKTYLKIIKDRRS--STE 252

  Fly   275 QLGQEDEFGKKQRYAMLDTLLAAE-ADGQ-IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALH 337
            ..|.:          |:.||::.: .||: :....|...:...:..|..|::..:::.|.:|...
pombe   253 NPGTD----------MIWTLMSCKYRDGRPLKEHEIAGMMIALLMAGQHTSAATIVWVLALLGSK 307

  Fly   338 EDVQKKCYEEIKYLPDDSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVVNG--LI 400
            .::.:..:||.|.:..::.::...|:.::..:..||:|:|||.|.:....|:...:..|.|  ::
pombe   308 PEIIEMLWEEQKRVVGENLELKFDQYKDMPLLNYVIQETLRLHPPIHSHMRKVKRDLPVPGSKIV 372

  Fly   401 MPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFA-----------------FVPF 448
            :|.|..:.........:..:|::...|.|.|:  .:.||....|                 ::||
pombe   373 IPANNYLLAAPGLTATEEEYFTHATDFDPKRW--NDRVNEDENAEQIDYGYGLVTKGAASPYLPF 435

  Fly   449 SAGQRNCIGQKFAILEIKVLLAAVIRNF 476
            .||:..|||::||.:.:..:::..:.::
pombe   436 GAGRHRCIGEQFAYMHLSTIISKFVHDY 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	84/483 (17%)
erg11	NP_592990.1	CypX	28..495	CDD:225035	84/483 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050