DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and cyp-37B1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_507109.1	Gene:	cyp-37B1 / 180093	WormBaseID:	WBGene00009226	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	163/533 - (30%)
Similarity:	278/533 - (52%)	Gaps:	49/533 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLEV--LFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSL---LESKIYVAPSKTRFGNNF 61
            ||.:  :|...:.:|.::.::..:...   |.:.|.:|..||..   :...:|:.       |.|
Worm     3 FLNIATIFLITIFLFYYKLIYNFIRDR---LRIYKYMRKFDGPYSFPIIGTLYMV-------NIF 57

  Fly    62 DLVNFTSESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKP 126
            |:..||::|: ...:....|..|...|| ....|:..::..:.|:|||:|:::|||...|::|.|
Worm    58 DISKFTTQSM-ELAQYYCQKGCGTIGLW-LGPVPLIAVINPQHAKEILESNEVITKAEEYDILFP 120

  Fly   127 FLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVL--HQSVNMELELNQVIP 189
            :||.|||.||..||..|||.||||||||||..||.:...:....::.:  :.....|::|...|.
Worm   121 WLGTGLLTSTGSKWRQRRKMLTPAFHFKVLNDFLSVHDYQAKVFLEQIKPYADSGKEVDLFPYIK 185

  Fly   190 QFTLNNVCETALGVKLD-DLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNL 253
            :..|:.:|:|::||.:| ..:...:|.:|:..:.|...:.:..|:......::|.|...:...:|
Worm   186 RLALDVICDTSMGVTIDAQNNHDHQYVESVRLLSEYAFEWILRPWLRLKPLWYLTGPGHEYDRHL 250

  Fly   254 KIAHEFSSNIIEKRRSLFKSNQLGQEDEFGK--KQRYAMLDTLLAAEADGQIDHQGICDEVNTFM 316
            ||..:|:..:|:::...|:...:   |...|  |:..|.||.||....:|.::...|.:||:|||
Worm   251 KIVTDFTKTVIKEKWEEFQKFHV---DPVVKTDKRSMAFLDLLLELRNEGLMNEDDIREEVDTFM 312

  Fly   317 FEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSD-DISVFQFNELVYMECVIKESLRLF 380
            |||:||||..:.:||..||.:.:.|:|..:|:..:...|| |.:.....::.|:|..:|||||::
Worm   313 FEGHDTTSASMGWTLWCLAHNPEFQEKVIQEVDGIFGTSDRDCTNDDLKQMKYLEKCLKESLRMY 377

  Fly   381 PSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAF 445
            |||||.||...::.|:||...||..:|.:....:.|:...|.||..:.|:.|..:...:||.::.
Worm   378 PSVPFFGRTVEQDVVINGDFFPKGVRIIVMPLLLQRNPLIFDNPNQYNPENFSEDKIGSRHAYSD 442

  Fly   446 VPFSAGQRNCIGQKFAILEIKVLLAAVIRNF-----------KILPVTLLDDLTFENGIVLRTKQ 499
            :|||||.|||||||||::|.|.:::...|.:           ||||           .::|::..
Worm   443 IPFSAGPRNCIGQKFAMMEEKAVISWFFRKYRVTASQPFGMNKILP-----------ELILKSSL 496

  Fly   500 NIKVKLVHR-ENK 511
            ...:.:.|| :||
Worm   497 GFPLTVHHRTDNK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	149/464 (32%)
cyp-37B1	NP_507109.1	p450	41..475	CDD:278495	146/445 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030