Protein Alignment Cyp4ac2 and cyp-25A2

DIOPT Version :10

• Sequence 1: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_497776.2
• Gene: cyp-25A2 / 175495
• WormBaseID: WBGene00007964
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 558
• Identity: 127/558 - (22%)
• Similarity: 216/558 - (38%)
• Gaps: 129/558 - (23%)

  Fly    11 LVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESI---- 71
            ||.||...|:|               |.|...|.|......|....|..|...:....|.:
 Worm    13 LVSFIIYILFA---------------RREQFKLREKIGLTGPEPHWFMGNLKQIVDRKEKLGYDD 62

  Fly    72 ----FNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPF----- 127
                ||.:.    |..|..:..||  ....|||.:.| |:|.:.......|....::.|.
 Worm    63 SNKWFNELH----KQYGETFGIYF--GAQMNIVLSNE-EDIKEVFIKNFSNFSDRIVPPIFDSNQ 120

  Fly   128 LGEGLLIST-DQKWHSRRKALTPAF---HFKVLQSFLIIFKEECNKLVKVLHQSVNMELE-LNQV 187
            |.:.||.:| ...|...|.|:.|.|   ..|.:|              :.:|..|::.|: |.:.
 Worm   121 LNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMQ--------------ETIHSKVDLFLDILREK 171

  Fly   188 IPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNN 252
            .......::.|...|:.||.:.      :...||:...|:...:.|:.|.         ||.:.|
 Worm   172 ASSGQKWDIYEDFQGLTLDVIG------KCAFAIDSNCQRDRNDVFYVNA---------RKFIAN 221

  Fly   253 LKIAH----------------------------------EFSSNIIEKRRSLFKSNQLGQEDEFG 283
            :.|.|                                  |..||:.|:||....|:.:.
 Worm   222 IDIRHSKVIAASFILPELAPLWRALYKYTPLADAEIPLVEGLSNVYERRRGGEGSDSVD------ 280

  Fly   284 KKQRYAMLDTLLAAEADGQ--IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYE 346
                  :|..||..|.|..  :..|.:.:....|:..||:||||.:.:...:|:.:.:||:|.||
 Worm   281 ------LLKLLLNREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYE 339

  Fly   347 EIKYLPDDSDDISVFQFNELVYMECVIKESLRLFPSV-PFIGRRCVEEGVVNGLIMPKNTQINIH 410
            ||....::. .::....:.:.|::.|.||:||.:|.| .||.|||:.:..:.|...||.:.:...
 Worm   340 EIMEAKENG-GLTYDSIHNMKYLDYVYKETLRCYPPVIHFINRRCLADITIRGQFYPKGSVVTCL 403

  Fly   411 LYEIMRDARHFSNPKMFQPDRFFPENTVNR-HPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIR 474
            .:.:..:..::.:|:.|.|:||  ||...: ....::||..|.|.|:|.:||.:|.|..:..::.
 Worm   404 PHTVHLNPENWDSPEEFHPERF--ENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIVKLLD 466

  Fly   475 NFKIL----PVTLLDDLTFENGIVLRTKQNIKVKLVHR 508
            .|::.    ...|:.|.   ||:::|.|..:::.|..|
 Worm   467 TFELKQFKGEADLIPDC---NGVIMRPKDPVRLLLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	CYP4	84..503	CDD:410721	108/470 (23%)
cyp-25A2	NP_497776.2	CYP3A-like	73..495	CDD:410678	108/471 (23%)