Protein Alignment Cyp4ac2 and CYP19A1

DIOPT Version :9

• Sequence 1: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 108/429 - (25%)
• Similarity: 190/429 - (44%)
• Gaps: 65/429 - (15%)

  Fly    84 GRNYLWYFFHAP--MYNIVRAE------EAEEILQSSKLITKNMIYELLK---------PFLG-- 129
            || :||....:.  .||.|..|      ..||.|..||   .:.::.::|         ..||
Human    63 GR-FLWMGIGSACNYYNRVYGEFMRVWISGEETLIISK---SSSMFHIMKHNHYSSRFGSKLGLQ 123

  Fly   130 ------EGLLISTD-QKWHSRR----KALTPAFHFKVLQSFLIIFKEECNKLVKVLHQS--VNME 181
                  :|::.:.: :.|.:.|    |||:.....:::.......|...::|.:|.::|  |::.
Human   124 CIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVL 188

  Fly   182 LELNQVIPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNP-FFYNIVYFFLFGD 245
            ..|.:|:    |:......|.:.||:.:..::    |....:..|..|..| .|:.|.:  |:..
Human   189 TLLRRVM----LDTSNTLFLRIPLDESAIVVK----IQGYFDAWQALLIKPDIFFKISW--LYKK 243

  Fly   246 YRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQIDHQGICD 310
            |.|.|.:||.|.|..  |.||||.:....:|.:..:|..:        |:.||..|.:..:.:..
Human   244 YEKSVKDLKDAIEVL--IAEKRRRISTEEKLEECMDFATE--------LILAEKRGDLTRENVNQ 298

  Fly   311 EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQFNELVYMECVIKE 375
            .:...:....||.|..|.|.|.::|.|.:|::...:||:.:..:. ||.:....:|..||..|.|
Human   299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDDIQKLKVMENFIYE 362

  Fly   376 SLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNR 440
            |:|..|.|..:.|:.:|:.|::|..:.|.|.|.:::..:.| ...|  ||   |:.|..||....
Human   363 SMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFF--PK---PNEFTLENFAKN 421

  Fly   441 HPFA-FVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKI 478
            .|:. |.||..|.|.|.|:..|::.:|.:|..::|.|.:
Human   422 VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	108/429 (25%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	104/419 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040