Protein Alignment Cyp4ac2 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 110/396 - (27%)
• Similarity: 202/396 - (51%)
• Gaps: 24/396 - (6%)

  Fly   127 FLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQ--SVNMELELNQVIP 189
            |:...:.|:.|::|...|..|:|.|....|:..:.|..:..:.||:.|.:  .....:.|..|..
Human   113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG 177

  Fly   190 QFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYF-FLFGDYRKQVNNL 253
            .::::.:..|:.||.:|.|:.  .....:...:::::....:|||.:|..| ||....  :|.|:
Human   178 AYSMDVITSTSFGVNIDSLNN--PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPIL--EVLNI 238

  Fly   254 KIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQID-HQGICD-----EV 312
            .:.....:|.:.|.....|.::|  ||.  :|.|...|..::.::...:.: |:.:.|     :.
Human   239 CVFPREVTNFLRKSVKRMKESRL--EDT--QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQS 299

  Fly   313 NTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEI-KYLPDDSDDI--SVFQFNELVYMECVIK 374
            ..|:|.||:|||:.|.|.:..||.|.|||:|..||| ..||:.:...  :|.|   :.|::.|:.
Human   300 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ---MEYLDMVVN 361

  Fly   375 ESLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVN 439
            |:|||||....:.|.|.::..:||:.:||...:.|..|.:.||.::::.|:.|.|:||..:|..|
Human   362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426

  Fly   440 RHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLD-DLTFENGIVLRTKQNIKV 503
            ..|:.:.||.:|.|||||.:||::.:|:.|..|::||...|..... .|....|.:|:.::.:.:
Human   427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491

  Fly   504 KLVHRE 509
            |:..|:
Human   492 KVESRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	108/390 (28%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	108/390 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910