DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4ac2 and Cyp4a12b

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus

Alignment Length:	534	Identity:	153/534 - (28%)
Similarity:	254/534 - (47%)	Gaps:	77/534 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLEVLFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNF----D 62
            :|:|.....|::.:|:....:|:|.:.:.|             ..:....||...||:..    |
Mouse    18 YLQVASVLSLLLLLFKTAQLYLHRQWLLSS-------------TQQFPSPPSHWLFGHKILKDQD 69

  Fly    63 LVNFTSESIFNFMRDASAKAKGRNYLW-----YFFHAPMYNIVRAEEAEEILQSSKLITKNMIYE 122
            |.:..:. |.||   .||..:   :||     ...:.|.|..:....::.....|        |.
Mouse    70 LQDILTR-IKNF---PSACPQ---WLWGSKVRIQVYDPDYMKLILGRSDPKAHGS--------YR 119

  Fly   123 LLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME--LELN 185
            .|.|::|.|||:...|.|...|:.||||||:.:|:.:..|..:..:.::....|.|..:  ||:.
Mouse   120 FLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIF 184

  Fly   186 QVIPQFTLNNVCETAL----GVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGD- 245
            |.|...||:.:.:.|.    .|:||.     :|:..|.|:|:     |.|.||..:...|...|
Mouse   185 QHITLMTLDTIMKCAFSHEGSVQLDR-----KYKSYIQAVED-----LNNLFFLRVRNIFHQNDI 239

  Fly   246 -YRKQVNN------LKIAHEFSSNIIEKRRSLFKSNQLGQEDE---FGKKQRYAMLDTLLAAEAD 300
             ||...|.      .::||:.:..:|:.|||     ||..|:|   ..||:|...||.||.|..:
Mouse   240 IYRVSSNGCLANSACQLAHDHTDQVIKSRRS-----QLQDEEELEKLKKKRRLDFLDILLFARME 299

  Fly   301 G--QIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQF 363
            .  .:..:.:..||:||||||:|||::.:.:....||.:.:.|::|.:||:.|..|...|:....
Mouse   300 NGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGASITWNDL 364

  Fly   364 NELVYMECVIKESLRLFPSVPFIGRRCVEEGVV--NGLIMPKNTQINIHLYEIMRDARHFSNPKM 426
            :::.|....|||:||::|.||.:.|. :...|.  :|..:||...:.:..|.:..:...:.||::
Mouse   365 DKMPYTTMCIKEALRIYPPVPSVSRE-LSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEV 428

  Fly   427 FQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFEN 491
            |.|.||.|.:  :||..:|:|||.|.|||||::||:.|:||.:|..:..|::||......:....
Mouse   429 FDPSRFAPGS--SRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPR 491

  Fly   492 GIVLRTKQNIKVKL 505
             |||::|..|.:.|
Mouse   492 -IVLKSKNGIHLHL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	143/477 (30%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	140/466 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850