DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	489	Identity:	112/489 - (22%)
Similarity:	205/489 - (41%)	Gaps:	73/489 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSESIFNFMRDASAK 81
            |.||..:.      |.|.......|..:  :::::..:|       |:...|.|:|:.|
Mouse    64 RFLWMGIG------SACNYYNKMYGEFM--RVWISGEET-------LIISKSSSMFHVM------ 107

  Fly    82 AKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKWHSRRKA 146
             |..:|:..|........:...|...|..::.     .::..::||.               .||
Mouse   108 -KHSHYISRFGSKRGLQCIGMHENGIIFNNNP-----SLWRTIRPFF---------------MKA 151

  Fly   147 LTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME-LELNQVIPQFTLNNVCETALGVKLDDLSE 210
            ||.....::::..:...|:..::|.:|...|..:: |.|.:.|...|.|.:   .||:.||:.:
Mouse   152 LTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNML---FLGIPLDESA- 212

  Fly   211 GIRYRQSIHAIEEVMQQRLCNP-FFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSN 274
               ..:.|.......|..|..| .|:.|.:  |:..|.:.|.:||  .|.:..:.:||..:..:.
Mouse   213 ---IVKKIQGYFNAWQALLIKPNIFFKISW--LYRKYERSVKDLK--DEIAVLVEKKRHKVSTAE 270

  Fly   275 QLGQEDEFGKKQRYAMLDTLLAAEADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHED 339
            :|....:|.        ..|:.||..|.:..:.:...:...:....||.|..|.|.||::|.:.:
Mouse   271 KLEDCMDFA--------TDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPE 327

  Fly   340 VQKKCYEEIKYLPDDSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVVNGLIMPKN 404
            |:....:||..:..|. ||.:.....|..:|..|.||:|..|.|..:.||.:|:.|::|..:.|.
Mouse   328 VEAAILKEIHTVVGDR-DIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKG 391

  Fly   405 TQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFA-FVPFSAGQRNCIGQKFAILEIKVL 468
            |.|.:::..:.| ..:|  ||   |:.|..||.....|:. |.||..|.|.|.|:..|::.:||:
Mouse   392 TNIILNIGRMHR-LEYF--PK---PNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVV 450

  Fly   469 LAAVIRNF--KILPVTLLDDLTFENGIVLRTKQN 500
            |..::|.|  |.|....::::..:|.:.|...::
Mouse   451 LVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNED 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	105/449 (23%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	112/489 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040