Protein Alignment Cyp4ac2 and CYP4F22

DIOPT Version :9

• Sequence 1: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 147/543 - (27%)
• Similarity: 260/543 - (47%)
• Gaps: 97/543 - (17%)

  Fly    11 LVIFIFRKL--WAHLNRTYFILSLCKRIRT------------EDGSLLESKIYVAPSKTRFGNNF 61
            |:.|:||.|  :..|.|:::|  .|:|:|.            ..|..|.::..:...|....|..
Human    31 LLFFLFRLLLRFLRLCRSFYI--TCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMH 93

  Fly    62 DLVNFTSESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLIT--KNMIYELL 124
            .::                      .:|.....|:..:|..:..:.:|.:|..|.  .::.|..|
Human    94 HVL----------------------LVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFL 136

  Fly   125 KPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLH---------QSVNM 180
            ||:||:|||:|...||...|:.|||||||.:|:.::.||    |:...::|         .:|::
Human   137 KPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIF----NQSADIMHAKWRHLAEGSAVSL 197

  Fly   181 EL----------ELNQVIPQFTLNNVCETALG------VKLDDLSEGIRYRQSIHAIEEVMQQRL 229
            ::          .|.:.:  |:.|:.|:..:.      ::|..||...:||  :|
Human   198 DMFEHISLMTLDSLQKCV--FSYNSNCQEKMSDYISAIIELSALSVRRQYR--LH---------- 248

  Fly   230 CNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAM--LD 292
               .:.:.:| :...|.|:......:.|.|::.:|::||...:  |.|.|.....||...:  :|
Human   249 ---HYLDFIY-YRSADGRRFRQACDMVHHFTTEVIQERRRALR--QQGAEAWLKAKQGKTLDFID 307

  Fly   293 T-LLAAEADG-QIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPD-- 353
            . |||.:.|| ::..:.|..|.:||||||:||||:.:.:.|..||.:.:.|:||.|||:.:..
Human   308 VLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGR 372

  Fly   354 DSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRRCVEE-GVVNGLIMPKNTQINIHLYEIMRD 417
            :.:::......:|.:....||||||.:|.|..:.|:|.|: .:.:|.|:||.....:.:|....:
Human   373 ELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHN 437

  Fly   418 ARHFSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVT 482
            ...:.:.|::.|.||.|:|...|.|.|:||||||.||||||.||:.|::|::|..:..|: |.|.
Human   438 PTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFR-LSVD 501

  Fly   483 LLDDLTFENGIVLRTKQNIKVKL 505
            ....:..:..::|||:..:.:|:
Human   502 RTRKVRRKPELILRTENGLWLKV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	132/481 (27%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	135/510 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850