DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	461	Identity:	139/461 - (30%)
Similarity:	224/461 - (48%)	Gaps:	90/461 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PMYNIVRAEEAEEILQSSKLIT-KNMI-YELLKPFLGEGLLISTDQKWHSRRKALTPAFHFKVLQ 157
            |:..:...:....:|.:|..:. |.:: |..|||:||:|||:|...||.|.|:.|||||||.:|:
Mouse   102 PIITLCHPDIIRSVLNASASVALKEVVFYSFLKPWLGDGLLLSDGDKWSSHRRMLTPAFHFNILK 166

  Fly   158 SFLIIFKEECNKLVKVLH-------QSVNMELELNQVIPQFTLNNV----------CE------- 198
            .::.||.:..|    ::|       ...:..|::.:.|...||:::          |:
Mouse   167 PYVKIFNDSTN----IMHAKWQHLASGGSARLDVFENISLMTLDSLQKCVFSFDSNCQENPSEYI 227

  Fly   199 ------TALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAH 257
                  :||..|        ||.|.:..|:.:.|.......|:...:               :.|
Mouse   228 SAILELSALVTK--------RYHQLLLHIDSLYQLTCSGRRFHKACH---------------LVH 269

  Fly   258 EFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLD----TLLAAEADG-QIDHQGICDEVNTFMF 317
            .|:..:|:.||....|..  ::|....|.:...||    .||:.:.|| ::..:.|..|.:||||
Mouse   270 SFTDAVIQDRRRTLPSKH--EDDVLKAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMF 332

  Fly   318 EGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSD------DISVF---QFNELVYMECVI 373
            ||:|||::.|.:.|..||.|.:.|::|.:|::.|..|.:      ..:||   ...:|.::...|
Mouse   333 EGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIECSCAVFLRDDLAQLPFLTMCI 397

  Fly   374 KESLRLFPSVPFIGRRCVEEGVV-NGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENT 437
            ||||||.|.|..|.|||.::.|: :|.::||.....|:::....:...:.:|:::.|.||.|||.
Mouse   398 KESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENI 462

  Fly   438 VNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDD----------LTFENG 492
            .:|.|.||:|||||.||||||.||:.|:||.||..:..|::||    ||          |..|.|
Mouse   463 KDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLP----DDKEPRRKPELILRAEGG 523

  Fly   493 IVLRTK 498
            :.||.:
Mouse   524 LWLRVE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	139/461 (30%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	137/456 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850