DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4ac2 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	521	Identity:	180/521 - (34%)
Similarity:	284/521 - (54%)	Gaps:	42/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTSES 70
            |..|.::|.||..|.::..:...:.|:....|..  .|:...:|:.|:...|..  .|:.:|.|
Mouse    24 LAGATILISIFPMLVSYARKWQQMRSIPSVARAY--PLVGHALYMKPNNAEFFQ--QLIYYTEE- 83

  Fly    71 IFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLIS 135
               |......|      || ....|:..:.:||..|.||.|||.|.|:.:|:.|:|:||.|||.|
Mouse    84 ---FRHLPIIK------LW-IGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTS 138

  Fly   136 TDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVNME-LELNQVIPQFTLNNVCET 199
            |..||.:|||.|||.|||.:|::||.:..|:.|.||..|.:.||.| ......|....|:.:|||
Mouse   139 TGSKWRTRRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICET 203

  Fly   200 ALGVKLDDLSEG-IRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRKQVNNLKIAHEFSSNI 263
            |:|..:...|.. ..|.::::.:.:::.:|:..|:.:..:::.:|.:.|.....||..|.|::|:
Mouse   204 AMGKNIGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNV 268

  Fly   264 IEKRRSLFKSNQLGQEDEFG--------KKQRYAMLDTLLAA--EADGQIDHQGICDEVNTFMFE 318
            |.:|    ...:..:||..|        |.:|.|.||.||:.  |...::..:.|.:||:|||||
Mouse   269 IAER----VKERKAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFE 329

  Fly   319 GYDTTSTCLIFTLLMLALHEDVQKKCYEEI------KYLPDDSDDISVFQFNELVYMECVIKESL 377
            |:|||:..:.::|.:|..:.:||:|..:|:      .:.|...:|:     .:|.|::|||||:|
Mouse   330 GHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDL-----KKLKYLDCVIKETL 389

  Fly   378 RLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHP 442
            |:|||||...|...|:..|.|..:.|.|:..|..|.:.||.|:|.:|:.|:|:||||||:..|||
Mouse   390 RVFPSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQGRHP 454

  Fly   443 FAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQNIKVKLVH 507
            :|:||||||.|||||||||::|.|.:||.::|.|.:......::|.....::||....|.:||..
Mouse   455 YAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILRPNNGIWIKLKR 519

  Fly   508 R 508
            |
Mouse   520 R 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	166/465 (36%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	170/489 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950