Protein Alignment Cyp4ac1 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 135/523 - (25%)
• Similarity: 241/523 - (46%)
• Gaps: 64/523 - (12%)

  Fly    11 LLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFTPASVFNFVR 75
            :|...:|:|.:|..|:             ...|..|:.| ||.|.. ..|..:.|....::||.|
Human    13 VLVATSLVLLYIYGTH-------------SHKLFKKLGI-PGPTPL-PFLGTILFYLRGLWNFDR 62

  Fly    76 ESTAKAKGQNYLWYFLYAPMYNVVRPEEAEEVF--QSTKLITKNVVYELIRP--FLGDGLLISTD 136
            |...| .|:.:..|....||..::.|:..:.|.  :...:.|..:.   :.|  ||...|..:.|
Human    63 ECNEK-YGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMP---LGPMGFLKSALSFAED 123

  Fly   137 HKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAELE------LNQVIPPFTLNNI 195
            .:|...|..|:|||.....:..:.|. .:|.   ::|.::|..|.|      |......:|::.|
Human   124 EEWKRIRTLLSPAFTSVKFKEMVPII-SQCG---DMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

  Fly   196 CETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNP-LMYYNWYFFV--------YGDYRKHLQN 251
            ..|..||.||.::  |.....:..::::|.....:| |:..:.:.|:        .|.:.|.
Human   185 TGTLFGVNLDSLN--NPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD--- 244

  Fly   252 LRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADGQIDHQGICD-----EV 311
              :.|...:.|...|..:.:.||...||.|.:     |:|:..:.|..   .|:.:.|     :.
Human   245 --VTHFLKNSIERMKESRLKDKQKHRVDFFQQ-----MIDSQNSKETK---SHKALSDLELVAQS 299

  Fly   312 NTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMFQFNKLVYLECVIKESL 376
            ...:|..||||||.|.|.:..||.|.|||:|..||::.:..:...::.....::.||:.|:.|:|
Human   300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETL 364

  Fly   377 RMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPD-RFLPENTVNRH 440
            |:||.|..:.|.|.::..:||:.:||...:.:.||.:..||:::.:|:.|.|: ||..:|..:..
Human   365 RLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSID 429

  Fly   441 PFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLE-DLTFENGIVLRTQENIKVKL 504
            .:.|:||.||.|||||.:||:..:|:.:...::||...|..:.: .|..:|..:|:.::.|.:|:
Human   430 LYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKV 494

  Fly   505 SKR 507
            ..|
Human   495 HLR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	115/444 (26%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	116/448 (26%)