Protein Alignment Cyp4ac1 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 544
• Identity: 130/544 - (23%)
• Similarity: 239/544 - (43%)
• Gaps: 103/544 - (18%)

  Fly    11 LLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFTPASVFNF-- 73
            :|.|.:|:|.:|..||             ...|..|:.| ||.    ..|.:|    .::||:
Mouse    13 VLLVTSLVLFYIYGTY-------------SHGLFKKLGI-PGP----KPLPLL----GTIFNYYD 55

  Fly    74 ----VRESTAKAKGQNYLWYFLYAP----------MYNVVRPEEAEEVFQSTKLITKNVVYELIR 124
                ..|...|..|:  :|.|...|          :..:|..:|...||.:.:         ...
Mouse    56 GMWKFDEDCYKKYGK--IWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR---------FFG 109

  Fly   125 P--FLGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAE------L 181
            |  |:...:.||.|.:|...|..|:|.|....|:....|.::    :.::|.:||..|      :
Mouse   110 PVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQ----YGDILVRNLRREEEKGEPI 170

  Fly   182 ELNQVIPPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLM------------- 233
            .:..:...::::.|..|:.||.:|.::  |.....:...:::|..::.:|.:
Mouse   171 SMKDIFGAYSMDVITGTSFGVNVDSLN--NPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIY 233

  Fly   234 -YYNWYFF------VYGDYRKHLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLD 291
             ..|:..|      .:..:.|.::..|:..:      ::.|..|.|..:...:..|::.:.|:.|
Mouse   234 EMLNFSIFPRDSMNFFKKFVKRMKKERLASN------QKNRVDFLQLMMNTQNSKGQESQKALSD 292

  Fly   292 TLLAAEADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDD 356
            ..:||:|             ..|:|.|||.|||.:...:..||.|.|||||..:|::....:...
Mouse   293 LEMAAQA-------------VIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAP 344

  Fly   357 ISMFQFNKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFP 421
            ::......:.||:.|:.||||::|....:.|...::..:||:.:||.|.:.|.||.:.|:|.::|
Mouse   345 VTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWP 409

  Fly   422 KPDLFQPDRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLE-D 485
            :|..|.|:||..||..|..|:.|:||..|.|||||.:||::.:|:.:..|::||.:.|..:.: .
Mouse   410 EPQEFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIP 474

  Fly   486 LTFENGIVLRTQENIKVKLSKRVK 509
            |......:.:.::.|.:|:..|.|
Mouse   475 LKISREPIFQPEKPIILKVVSRDK 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	109/457 (24%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	109/460 (24%)