Protein Alignment Cyp4ac1 and CYP27C1

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 114/494 - (23%)
• Similarity: 219/494 - (44%)
• Gaps: 71/494 - (14%)

  Fly    36 RTED------GSPL-------ESKVAIMPGKTRFGNNLDILNFTPASVFNFVRESTAKAKGQNYL 87
            |.||      |||.       ...:|.|||.....|..:.......|..:.:::...:..|:.:.
Human    42 RAEDKGAGRPGSPPGGGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFK 106

  Fly    88 WYFLYAPMY--NVVRPEEAEEVFQSTKLITKNVVYELIRPF-----LGDGLLISTDHKWHSRRKA 145
            .:|  .|.:  ::...:...:|.::.....:....|..|.:     ...||:.:...:|...|..
Human   107 SHF--GPQFVVSIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSV 169

  Fly   146 LTPAFHFNVLQ-SFLGIFKEECKKFLNVLEKNL--------DAE--LELNQVIPPFTLNNIC--- 196
            |..    .:|: ..:.|:..|..:.:..|.|.:        |.|  ..:|.:...:::..:.
Human   170 LRQ----RILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATIL 230

  Fly   197 -ETALGVKLDDMSEGN-EYRKAIHAIEEVLIQRVCNPLMYY----NWYF-FVYGDYRKHLQNLRI 254
             |:.||...:.:.:.. ||   |.|:|  |:..:....||.    .|.. |:...:|:..::...
Human   231 YESRLGCLENSIPQLTVEY---IEALE--LMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDG 290

  Fly   255 VHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADGQIDHQGICDEVNTFMFEGY 319
            :..||...::.|.:..|.:.     :.||:....:|..|..::|   :..|.|...|...:..|.
Human   291 LFKFSQIHVDNKLRDIQYQM-----DRGRRVSGGLLTYLFLSQA---LTLQEIYANVTEMLLAGV 347

  Fly   320 DTTSTCLIFTLLMLALHEDVQKKCYEE-VENLPE----DSDDISMFQFNKLVYLECVIKESLRMF 379
            ||||..|.:|:.:||.|.:||:..|.| |:||.|    .:.|:.     |:..:..::||:||:|
Human   348 DTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVP-----KVPLVRALLKETLRLF 407

  Fly   380 PSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPENTVNR-HPFA 443
            |.:|..||...|:.|:.|.::||.||:::..|.......:||:...|:|:|:|.:..::| ..|.
Human   408 PVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFG 472

  Fly   444 YVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQ 482
            .:||..|.|:|||::.|.||:.:::..::::|::..::|
Human   473 SIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQ 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	102/434 (24%)
CYP27C1	NP_001354431.1	CYP27C1	98..530	CDD:410740	102/438 (23%)