Protein Alignment Cyp4ac1 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 542
• Identity: 139/542 - (25%)
• Similarity: 247/542 - (45%)
• Gaps: 88/542 - (16%)

  Fly     3 IALLGIPILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFTP 67
            ::|..:.:|..:|.||.::..:|:   .|.|:.......||..          .|.   :||:.
Mouse     7 LSLDTLVLLAIILVLLYRYGTRTH---GLFKKQGIPGPKPLPF----------LGT---VLNYY- 54

  Fly    68 ASVFNFVRESTAKAKGQNYLWYFLYAPMYNVVRPEEAEEVFQSTKLITKNVVYELIRPF-----L 127
            ..::.|..|...| .|:.:..:....|:..:..||..:.|.....|    .|:...|.|     :
Mouse    55 TGIWKFDMECYEK-YGKTWGLFDGQTPLLVITDPETIKNVLVKDCL----SVFTNRREFGPVGIM 114

  Fly   128 GDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAELE------LNQV 186
            ...:.||.|.:|...|..|:|.|....|:....:.::    :.::|.|.|..|.|      :..|
Mouse   115 SKAISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQ----YGDILVKYLRQEAEKGMPVAMKDV 175

  Fly   187 IPPFTLNNICETALGVKLDDMS--------EGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYG 243
            :..::::.|..|:.||.:|.::        |..::.: :...:.:|...|..||:..     ||
Mouse   176 LGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLR-VDFFDPLLFSVVLFPLLTP-----VY- 233

  Fly   244 DYRKHLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLL------------AA 296
                .:.|:.:..:.|....::...:.|:.:|    :..:|.|...|..::            .|
Mouse   234 ----EMLNICMFPNDSIEFFKKFVDRMQESRL----DSNQKHRVDFLQLMMNSHNNSKDKDSHKA 290

  Fly   297 EADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVEN-LPEDSD---DI 357
            .::.:|..|.|     .|:..||:|||:.|.|||..||.|.|:|||...|::. ||..:.   |.
Mouse   291 FSNMEITVQSI-----IFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNKATPTCDT 350

  Fly   358 SMFQFNKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPK 422
            .|    ::.||:.|:.|:||::|.|..:.|.|.::..:||:.:||.:.:.|..|.:..||:|:|.
Mouse   351 VM----EMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHDPQHWPD 411

  Fly   423 PDLFQPDRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPA--TQLED 485
            |:.|||:||..||..:..|:.|:||..|.|||||.:||::.||:.:..|::||...|.  ||:..
Mouse   412 PEEFQPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPL 476

  Fly   486 LTFENGIVLRTQENIKVKLSKR 507
            .....|| |:.::.|.:|:..|
Mouse   477 KLSRQGI-LQPEKPIVLKVVPR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	121/455 (27%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	122/459 (27%)