Protein Alignment Cyp4ac1 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 184/524 - (35%)
• Similarity: 297/524 - (56%)
• Gaps: 24/524 - (4%)

  Fly     1 MWIALLGIPILL--AVLTLLLKHINKTYFILSLTKRV-----RTEDGSPLESKVAIMPGKTRFGN 58
            :|:.|:...:||  |...|.|...:   .:|||.:||     :.:...|:.:.....|   ..|:
Human     4 LWLGLVWQKLLLWGAASALSLAGAS---LVLSLLQRVASYARKWQQMRPIPTVARAYP---LVGH 62

  Fly    59 NLDILNFTPASVFNFVRESTAKAKGQNYLWYFL-YAPMYNVVRPEEAEEVFQSTKLITKNVVYEL 122
            .| ::.......|..:.|.|.:.:....|..:: ..||..:...|..|.:..|:|.|.|:.:|:.
Human    63 AL-LMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKF 126

  Fly   123 IRPFLGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAE-LELNQV 186
            :.|:||.|||.||.:||.||||.|||.|||.:|:.||.|..|:....:..|||:::.| ......
Human   127 LEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFY 191

  Fly   187 IPPFTLNNICETALGVKLDDMS-EGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDYRKHLQ 250
            |....|:.|||||:|..:...| :.:||.:|::.:.|::.:|:..|.::.:.::.::.:..:|.:
Human   192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK 256

  Fly   251 NLRIVHDFSSRIIERKRQQFQQKQLGEVDEFG----RKQRYAMLDTLLAAEAD--GQIDHQGICD 309
            :|:|:|.|::.:|..:..:....:....|..|    :.:|.|.||.||:...|  .::.|:.|.:
Human   257 SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIRE 321

  Fly   310 EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSD-DISMFQFNKLVYLECVIK 373
            ||:||||||:|||:..:.::|.:|..:.:||||...|::::...|| ..::....||.|||||||
Human   322 EVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIK 386

  Fly   374 ESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPENTVN 438
            |:||:|||||...|...|:..|.|..:.|.|:..|..|.:.||||:||.|:.|||:||.|||...
Human   387 ETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQG 451

  Fly   439 RHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQENIKVK 503
            |||:||||||||.|||||||||::|.|.:|:.::|:|.:....:.|:|..|..::||....|.:|
Human   452 RHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIK 516

  Fly   504 LSKR 507
            |.:|
Human   517 LKRR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	162/428 (38%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	164/438 (37%)