Protein Alignment Cyp4ac1 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 141/522 - (27%)
• Similarity: 260/522 - (49%)
• Gaps: 51/522 - (9%)

  Fly     5 LLGIPILLAVLTLLLK----HINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNF 65
            :|.:..||.:|.||:|    ::::.:.:.:|             .:....|....||:   |..|
Human    18 ILQVTSLLILLLLLIKAAQLYLHRQWLLKAL-------------QQFPCPPSHWLFGH---IQEF 66

  Fly    66 TPASVFNFVRE--STAKAKGQNYLW-----YFLYAPMYNVVRPEEAEEVFQSTKLITKNVVYELI 123
            ........::|  .|..:....::|     ..||.|.|..|....::.....:        |:.:
Human    67 QHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS--------YKFL 123

  Fly   124 RPFLGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNL--DAELELNQV 186
            .|.:|.|||:.....|...|:.||||||.::|:.::|:..:..:..|:..|:.|  |:.||:.|.
Human   124 APRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQH 188

  Fly   187 IPPFTLNNICETAL----GVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDYRK 247
            :...||:.|.::|.    .:::|..|:  .|.:||..:..::...:.|.....:..:.:....|.
Human   189 VSLMTLDTIMKSAFSHQGSIQVDRNSQ--SYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRW 251

  Fly   248 HLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEAD-GQI-DHQGICDE 310
            ..:..::.|..:.::|:.::.|.|::  ||:::..||:....||.||.|:.: |.| ..:.:..|
Human   252 THRACQLAHQHTDQVIQLRKAQLQKE--GELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAE 314

  Fly   311 VNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMFQFNKLVYLECVIKES 375
            |:||||||:|||::.:.:.|..||.|...|::|.||:..|..|...|:....:::.|....|||:
Human   315 VDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEA 379

  Fly   376 LRMFPSVPFIGRQ-CVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPENTVNR 439
            ||::|.||.|||: ....|..:|..:||...:.:.||.:..:|:.:|..::|.|.||.|.:.  :
Human   380 LRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSA--Q 442

  Fly   440 HPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQENIKVKL 504
            |..|::|||.|.|||||::||:.::||..|..:..|:|||......:.... :||:::..|.::|
Human   443 HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMAR-LVLKSKNGIHLRL 506

  Fly   505 SK 506
            .:
Human   507 RR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	125/432 (29%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	127/447 (28%)