Protein Alignment Cyp4ac1 and cyp-25A4

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_497779.1
• Gene: cyp-25A4 / 183248
• WormBaseID: WBGene00007967
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 547
• Identity: 122/547 - (22%)
• Similarity: 236/547 - (43%)
• Gaps: 102/547 - (18%)

  Fly    10 ILLAVLTLLLKHINKTYFILSLTKRVRTEDGSP------LESKVAIMPGK-TRFGNNLDILNFTP 67
            |...::|.:...|.:.:.|..|    |:..|.|      |...:.|:..: :|.|.| |...:.|
 Worm     9 IFFTIITFISYSIWRRHAIFKL----RSSIGIPGPPVHWLWGNLNIIKDRVSRLGYN-DTTQWHP 68

  Fly    68 ASVFNFVRESTAKAKGQNYLWYFLYAPMY----------NVVRPEEAEEVF-QSTKLITKNVVYE 121
                      |...|         |.|::          .|...|:.:|:| |:....:..:..:
 Worm    69 ----------TLHTK---------YGPIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPD 114

  Fly   122 LI-RPFLGDGLLIST-DHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDA--ELE 182
            :. ...|...||.:| ...|...|.|:.|.|....:::.......:...||.||::...:  :.:
 Worm   115 IFGMNQLNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSGQKWD 179

  Fly   183 LNQVIPPFTLNNICETALGVKLDDMSEGNEY-----RKAIHAIE----EVLIQRVCNPLMYYNWY 238
            :.:.....:|:.|.:.|..:..:...:..:.     ||.:.|::    .:|...:..|.:.:.|
 Worm   180 IFENFQSLSLDIIGKCAFAIDSNCQRDRTDLFYVQARKFVGAVDLKKSWILPVSLILPELSWLW- 243

  Fly   239 FFVYGDYRKHLQNLRIVHDFSS------RIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAE 297
                          |.::.||.      .:::.....:.:::.||    |......:|:.|:..|
 Worm   244 --------------RFLYKFSDLSAAELPLVKGLVDLYDRRRAGE----GGNDSTDLLNLLIRRE 290

  Fly   298 ADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMFQF 362
            ..|::..:.:.:....|:..||:||||.::|:..:||.:..||:|.|||::...|:: .::....
 Worm   291 TIGKMTQREVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKTKENA-GLNYDSI 354

  Fly   363 NKLVYLECVIKESLRMF-PSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLF 426
            :.:.||:||.|||||.: |:..|..|.|:.:..:.|.:.|:|:.:.:..|.|.|:|.::..||.|
 Worm   355 HNMKYLDCVYKESLRFYPPTTHFTNRVCLNDMTIRGQIYPEDSTLKVQPYTIHRNPANWESPDEF 419

  Fly   427 QPDRFLPENTVNR-HPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKL---------LPAT 481
            ||:||  ||...: ....::||..|.|.|:|.:||.:|.|..:|.::..|:|         :|.|
 Worm   420 QPERF--ENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELSLVPGDPPMIPET 482

  Fly   482 QLEDLTFENGIVLRTQENIKVKLSKRV 508
                    ||::.|.:..:::.|..|:
 Worm   483 --------NGVIFRPRSPVRLNLKLRI 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	103/459 (22%)
cyp-25A4	NP_497779.1	CYP3A-like	73..494	CDD:410678	104/459 (23%)