Protein Alignment Cyp4ac1 and cyp-25A2

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_497776.2
• Gene: cyp-25A2 / 175495
• WormBaseID: WBGene00007964
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 558
• Identity: 131/558 - (23%)
• Similarity: 234/558 - (41%)
• Gaps: 110/558 - (19%)

  Fly     3 IALLGIPILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIM-PGKTRFGNNL------ 60
            :|||   ||.::|.||:..|  .|.:.:..::.:      |..|:.:. |....|..||
 Worm     1 MALL---ILTSILILLVSFI--IYILFARREQFK------LREKIGLTGPEPHWFMGNLKQIVDR 54

  Fly    61 -DILNFTPASV-FNFVRESTAKAKGQNYLWYFLYAPMYNVV--RPEEAEEVFQSTKLITKNVVYE 121
             :.|.:..::. ||.:.    |..|:.:..||  ....|:|  ..|:.:|||...   ..|....
 Worm    55 KEKLGYDDSNKWFNELH----KQYGETFGIYF--GAQMNIVLSNEEDIKEVFIKN---FSNFSDR 110

  Fly   122 LIRPF-----LGDGLLIST-DHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAE 180
            ::.|.     |...||.:| ...|...|.|:.|.|....:::.......:...||::|.:...:.
 Worm   111 IVPPIFDSNQLNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMQETIHSKVDLFLDILREKASSG 175

  Fly   181 LELNQVIPPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDY 245
            .:.          :|.|...|:.||.:.      |...||:. ..||..|.:.|.|        .
 Worm   176 QKW----------DIYEDFQGLTLDVIG------KCAFAIDS-NCQRDRNDVFYVN--------A 215

  Fly   246 RKHLQNLRIVH---------------------------DFSSRIIERKRQQFQQKQLGE----VD 279
            ||.:.|:.|.|                           |....::|.....:::::.||    ||
 Worm   216 RKFIANIDIRHSKVIAASFILPELAPLWRALYKYTPLADAEIPLVEGLSNVYERRRGGEGSDSVD 280

  Fly   280 EFGRKQRYAMLDTLLAAEADGQ--IDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKK 342
                     :|..||..|.|..  :..|.:.:....|:..||:||||.:.:...:|:.:.:||:|
 Worm   281 ---------LLKLLLNREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQK 336

  Fly   343 CYEEVENLPEDSDDISMFQFNKLVYLECVIKESLRMFPSV-PFIGRQCVEETVVNGMVMPKDTQI 406
            .|||:....|:. .::....:.:.||:.|.||:||.:|.| .||.|:|:.:..:.|...||.:.:
 Worm   337 LYEEIMEAKENG-GLTYDSIHNMKYLDYVYKETLRCYPPVIHFINRRCLADITIRGQFYPKGSVV 400

  Fly   407 SIHIYDIMRDPRHFPKPDLFQPDRFLPENTVNR-HPFAYVPFSAGQRNCIGQKFAILEMKVLLAA 470
            :...:.:..:|.::..|:.|.|:||  ||...: ....::||..|.|.|:|.:||.:|.|..:..
 Worm   401 TCLPHTVHLNPENWDSPEEFHPERF--ENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIVK 463

  Fly   471 VIRNFKLLPATQLEDLTFE-NGIVLRTQENIKVKLSKR 507
            ::..|:|.......||..: ||:::|.::.:::.|..|
 Worm   464 LLDTFELKQFKGEADLIPDCNGVIMRPKDPVRLLLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	109/462 (24%)
cyp-25A2	NP_497776.2	CYP3A-like	73..495	CDD:410678	109/463 (24%)