Protein Alignment Cyp4ac1 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 117/515 - (22%)
• Similarity: 211/515 - (40%)
• Gaps: 99/515 - (19%)

  Fly     6 LGIPILLA------VLTLLLKHINKTYFILSLTKRVRTED-----GSPLESKVAIMPGKTR---F 56
            :|:|.|||      ||.|||       |:.:    ::..|     |......:.:.||...   |
Human     1 MGLPALLASALCTFVLPLLL-------FLAA----IKLWDLYCVSGRDRSCALPLPPGTMGFPFF 54

  Fly    57 GNNLDILNFTPASVFNFVRESTAKAKGQNYLWYFLY------APMYNVVRPEEAEEVFQSTKLIT 115
            |..|.::         ..|....:.|.:.|  .|:|      .|...|:..:....:......:.
Human    55 GETLQMV---------LQRRKFLQMKRRKY--GFIYKTHLFGRPTVRVMGADNVRRILLGEHRLV 108

  Fly   116 KNVVYELIRPFLGDGLLIS---TDHKWHSRRKALTPAFHFNVLQSFLGIFKEE----CKKFLNVL 173
            .......:|..||.|.|.:   :.||  .|:|.:..||....|:.::.:..||    .:::|:..
Human   109 SVHWPASVRTILGSGCLSNLHDSSHK--QRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCG 171

  Fly   174 EKNLDAELELNQVIPPFTLNNI--CETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYN 236
            |:.|....|:.:::....:..:  ||..|.      .:|:..::.:.|.||:
Human   172 ERGLLVYPEVKRLMFRIAMRILLGCEPQLA------GDGDSEQQLVEAFEEM------------- 217

  Fly   237 WYFFVYGDYRKHLQNLRIVHDFS---------SRIIERKRQQFQQKQLG-EVDEFGRKQRYAMLD 291
                     .::|.:|.|...||         :.|..|..|..:.|..| ...|.|:..:.| |.
Human   218 ---------TRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDA-LQ 272

  Fly   292 TLL--AAEADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVEN---LP 351
            .|:  :.|...::|.|.:.......:|.|::||::.....:..|.|:..|.:|..||:::   |.
Human   273 LLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLC 337

  Fly   352 EDSDD--ISMFQFNKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIM 414
            :.:.|  :.|....:|.|:.|||||:||:.|.||...|..::...:||..:||...:...|.|..
Human   338 KSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTH 402

  Fly   415 RDPRHFPKPDLFQPDRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRN 474
            .....|...:.|.||||:..:..:...|:::||..|.|:|:|::||.:.:|:....:.|:
Human   403 DVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	97/424 (23%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	101/450 (22%)