Protein Alignment Cyp4ac1 and CYP19A1

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 119/526 - (22%)
• Similarity: 221/526 - (42%)
• Gaps: 87/526 - (16%)

  Fly    17 LLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFTPASVFNFVRESTAKA 81
            ::|:.:|..::  ::|..|      |.....|.||.....|..|.:.|:          |.|:..
Human     1 MVLEMLNPIHY--NITSIV------PEAMPAATMPVLLLTGLFLLVWNY----------EGTSSI 47

  Fly    82 KGQNY-------------LW--------YF--LYAPMYNV-VRPEEAEEVFQSTKL--ITKNVVY 120
            .|..|             ||        |:  :|.....| :..||...:.:|:.:  |.|:..|
Human    48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHY 112

  Fly   121 ------ELIRPFLG---DGLLISTDHK-WHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEK 175
                  :|....:|   .|::.:.:.: |.:.|.....|.....|...:.:..|..|..|:.||:
Human   113 SSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEE 177

  Fly   176 --NLDAELELNQVIPPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYY--N 236
              |....:::..::....|:......|.:.||:.:...:.:....|.:.:||:    |.:::  :
Human   178 VTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIK----PDIFFKIS 238

  Fly   237 WYFFVYGDYRKHLQNLRIVHDFSSRIIERKRQQFQ-QKQLGEVDEFGRKQRYAMLDTLLAAEADG 300
            |   :|..|.|.:::|:   |....:|..||::.. :::|.|..:|..:        |:.||..|
Human   239 W---LYKKYEKSVKDLK---DAIEVLIAEKRRRISTEEKLEECMDFATE--------LILAEKRG 289

  Fly   301 QIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMFQFNKL 365
            .:..:.:...:...:....||.|..|.|.|.::|.|.:|::...:|::.:..:. ||.:....||
Human   290 DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDDIQKL 353

  Fly   366 VYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDR 430
            ..:|..|.||:|..|.|..:.|:.:|:.|::|..:.|.|.|.::| ..|.....|||     |:.
Human   354 KVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNI-GRMHRLEFFPK-----PNE 412

  Fly   431 FLPENTVNRHPFAYV-PFSAGQRNCIGQKFAILEMKVLLAAVIRNF--KLLPATQLEDLTFENGI 492
            |..||.....|:.|. ||..|.|.|.|:..|::.||.:|..::|.|  |.|....:|.:...:.:
Human   413 FTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDL 477

  Fly   493 VLRTQE 498
            .|...|
Human   478 SLHPDE 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	106/460 (23%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	102/437 (23%)